Department of Obstetrics & Gynecology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ann Lab Med. 2012 May;32(3):194-200. doi: 10.3343/alm.2012.32.3.194. Epub 2012 Apr 18.
To investigate the risk factors for vaginal infections and antimicrobial susceptibilities of vaginal microorganisms among women who experienced preterm birth (PTB), we compared the prevalence of vaginal microorganisms between women who experienced preterm labor (PTL) without preterm delivery and spontaneous PTB.
Vaginal swab specimens from 126 pregnant women who experienced PTL were tested for group B streptococcus (GBS), Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, Chlamydia trachomatis, Trichomonas vaginalis, Neisseria gonorrhoeae, Treponema pallidum, herpes simplex virus (HSV) I and II, and bacterial vaginosis. A control group of 91 pregnant women was tested for GBS. Antimicrobial susceptibility tests were performed for GBS, M. hominis, and U. urealyticum.
The overall detection rates for each microorganism were: U. urealyticum, 62.7%; M. hominis, 12.7%; GBS, 7.9%; C. trachomatis, 2.4%; and HSV type II, 0.8%. The colonization rate of GBS in control group was 17.6%. The prevalence of GBS, M. hominis, and U. urealyticum in PTL without preterm delivery and spontaneous PTB were 3.8% and 8.7% (relative risk [RR], 2.26), 3.8% and 17.3% (RR, 4.52), and 53.8% and 60.9% (RR, 1.13), respectively, showing no significant difference between the 2 groups. The detection rate of M. hominis by PCR was higher than that by culture method (11.1% vs. 4.0%, P=0.010). The detection rates of U. urealyticum by PCR and culture method were 16.7% and 57.1%, respectively.
There was no significant difference in the prevalence of GBS, M. hominis, and U. urealyticum between the spontaneous PTB and PTL without preterm delivery groups.
为了研究早产（PTB）孕妇阴道感染的危险因素和阴道微生物的抗菌药物敏感性，我们比较了有早产但未分娩（PTL）和自发性 PTB 孕妇的阴道微生物流行率。
对 126 例发生 PTL 的孕妇的阴道拭子标本进行 B 群链球菌（GBS）、人型支原体、生殖支原体、解脲脲原体、沙眼衣原体、阴道毛滴虫、淋病奈瑟菌、梅毒螺旋体、单纯疱疹病毒（HSV）I 型和 II 型和细菌性阴道病的检测。对 91 例孕妇进行 GBS 检测作为对照组。对 GBS、人型支原体和解脲脲原体进行抗菌药物敏感性试验。
每种微生物的总检出率分别为：解脲脲原体 62.7%；人型支原体 12.7%；GBS 7.9%；沙眼衣原体 2.4%；HSV 型 II 型 0.8%。对照组 GBS 的定植率为 17.6%。无早产分娩和自发性 PTB 的 PTL 中 GBS、人型支原体和解脲脲原体的流行率分别为 3.8%和 8.7%（相对风险 [RR]，2.26）、3.8%和 17.3%（RR，4.52）和 53.8%和 60.9%（RR，1.13），两组间无显著差异。PCR 法检测人型支原体的检出率高于培养法（11.1% vs. 4.0%，P=0.010）。PCR 和培养法检测解脲脲原体的检出率分别为 16.7%和 57.1%。
自发性 PTB 组和无早产分娩的 PTL 组的 GBS、人型支原体和解脲脲原体的流行率无显著差异。
