血清骨桥蛋白水平对小细胞肺癌的预后意义。
Prognostic significance of serum osteopontin levels in small cell lung cancer.
机构信息
Department of Respiratory Medicine, the Affiliated Brain Hospital of Nanjing Medical University, 215 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
The Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210029, Jiangsu, China.
出版信息
BMC Pulm Med. 2020 Sep 1;20(1):235. doi: 10.1186/s12890-020-01242-3.
BACKGROUND
Osteopontin (OPN) is closely related to tumor occurrence and metastasis. This study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients.
METHODS
The ELISA method was used to determine the OPN level of 96 SCLC patients before and after first-line chemotherapy, and compared with 60 healthy controls.
RESULTS
The serum OPN level of SCLC patients before treatment was significantly higher than that of the healthy control (P < 0.001). Serum OPN levels were related to disease stage, tumor size, and lymph node metastasis (P = 0.012, 0.034, and 0.037, respectively). Serum OPN level decreased after first-line chemotherapy (P = 0.019), which was related to treatment response (P = 0.011). The serum OPN level was an independent predictor of overall survival.
CONCLUSIONS
The serum OPN level can be used as a biomarker to predict treatment response and survival of SCLC patients.
背景
骨桥蛋白（OPN）与肿瘤的发生和转移密切相关。本研究探讨了血清 OPN 水平在小细胞肺癌（SCLC）患者中的临床价值。
方法
采用 ELISA 法检测 96 例 SCLC 患者一线化疗前后及 60 例健康对照者的 OPN 水平。
结果
治疗前 SCLC 患者血清 OPN 水平明显高于健康对照组（P<0.001）。血清 OPN 水平与疾病分期、肿瘤大小和淋巴结转移有关（P=0.012、0.034 和 0.037）。一线化疗后血清 OPN 水平降低（P=0.019），与治疗反应有关（P=0.011）。血清 OPN 水平是总生存的独立预测因子。
结论
血清 OPN 水平可作为预测 SCLC 患者治疗反应和生存的生物标志物。
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