Kaneuchi Yoichi, Fujiwara Tomohiro, Tsuda Yusuke, Yoshida Shinichirou, Stevenson Jonathan D, Abudu Adesegun
Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK.
J Child Orthop. 2020 Aug 1;14(4):330-334. doi: 10.1302/1863-2548.14.200046.
Chondrosarcomas typically present in adults during the fifth to seventh decades and are rare in young patients. The biological behaviour and oncological outcomes may be different in children and adolescents.
We retrospectively evaluated the outcomes of all patients with chondrosarcoma of bone who were younger than 18 years of age at the time of diagnosis and were treated at our centre between 1995 and 2018.
The 15 consecutive patients studied included nine male and six female cases, with a mean age at diagnosis of 13 years (7 to 17). The median follow-up was 117 months (30 to 277). The tumours were primary and secondary in ten and five patients, respectively. The tumours were central in 13 and surface in two patients. The tumour locations were the humerus in five, digits in five, femur in three, radius in one and pelvis in one patient. The histological grades were grade I in seven, grade II in seven and grade III in one patient. The surgical treatments were limb salvage in ten patients and ray amputation in five patients. The surgical margins were wide in eight, marginal in two and intralesional in five patients. All the patients were alive and continuously free of disease at the time of the last follow-up. No patient developed metastases or local recurrence.
Chondrosarcoma of bone in children and adolescent patients has a very good prognosis and is less aggressive compared with published outcomes in older patients.
IV.
软骨肉瘤通常在成人的第五至第七个十年出现，在年轻患者中罕见。儿童和青少年的生物学行为和肿瘤学结局可能有所不同。
我们回顾性评估了1995年至2018年期间在我们中心接受治疗、诊断时年龄小于18岁的所有骨软骨肉瘤患者的结局。
连续研究的15例患者中，男性9例，女性6例，诊断时的平均年龄为13岁（7至17岁）。中位随访时间为117个月（30至277个月）。肿瘤分别为原发性和继发性，各有10例和5例。13例肿瘤位于中央，2例位于表面。肿瘤部位分别为：肱骨5例，手指5例，股骨3例，桡骨1例，骨盆1例。组织学分级为I级7例，II级7例，III级1例。手术治疗包括10例保肢手术和5例截指手术。手术切缘8例为广泛切缘，2例为边缘切缘，5例为囊内切缘。在最后一次随访时，所有患者均存活且无疾病复发。无患者发生转移或局部复发。
儿童和青少年骨软骨肉瘤的预后非常好，与老年患者已发表的结局相比，侵袭性较小。
IV级。
