Szlendak Małgorzata, Sitarz Robert, Berbecka Monika, Mielko Jerzy, Morsink Folkert, Maciejewski Ryszard, Offerhaus G Johan A, Polkowski Wojciech P
Department of Human Anatomy, Medical University of Lublin, Lublin 20-090, Poland.
Department of Surgical Oncology, Medical University of Lublin, Lublin 20-090, Poland.
Mol Clin Oncol. 2020 Nov;13(5):52. doi: 10.3892/mco.2020.2122. Epub 2020 Aug 20.
In colorectal cancer (CRC), pathological factors that correlate with negative prognosis include, among others, overexpression of cyclooxygenase-2 (COX-2) and abundant expression of mucin 1 (MUC1). COX-2 overexpression may therefore be associated with MUC1 overexpression. The aim of the present study was to investigate the possible correlation between COX-2 and MUC1 expression and to assess the correlation between their individual expression and the clinicopathological features of patients, paying particular attention to survival. The following data was collected from the 170 patients with CRC included in the present study: Age, sex, tumour localization, disease stage and survival. Tumour samples were immunostained with antibodies against COX-2 and MUC1. Protein expression was scored, relative to reference staining, and correlated with the clinicopathological data of patients. The results revealed no correlation between the expressions of COX-2 and MUC1, or with any of the studied clinicopathological variables. In addition, the expression of the two proteins were not associated. Neither of the proteins demonstrated prognostic value for survival. The present study did not confirm a direct relationship between the expressions of COX-2 and MUC1, or between the expression of either protein and the clinicopathological features of patients, including survival.
在结直肠癌（CRC）中，与不良预后相关的病理因素包括环氧合酶-2（COX-2）的过表达和黏蛋白1（MUC1）的大量表达等。因此，COX-2过表达可能与MUC1过表达相关。本研究的目的是探讨COX-2与MUC1表达之间可能存在的相关性，并评估它们各自的表达与患者临床病理特征之间的相关性，尤其关注生存率。从本研究纳入的170例CRC患者中收集了以下数据：年龄、性别、肿瘤定位、疾病分期和生存率。用抗COX-2和MUC1抗体对肿瘤样本进行免疫染色。相对于对照染色对蛋白质表达进行评分，并与患者的临床病理数据相关联。结果显示，COX-2和MUC1的表达之间，或与任何研究的临床病理变量之间均无相关性。此外，这两种蛋白质的表达也不相关。这两种蛋白质均未显示出对生存率的预后价值。本研究未证实COX-2和MUC1的表达之间，或任何一种蛋白质的表达与患者的临床病理特征（包括生存率）之间存在直接关系。
