Reikerås O, Nordstrand K, Henden T
Institute of Clinical Medicine, University of Tromsø, Norway.
Scand J Clin Lab Invest. 1988 May;48(3):285-8. doi: 10.3109/00365518809167496.
The effect of intravenous infusion of glucose, insulin and potassium (GIK) on the glycogen contents of the heart, skeletal muscle and liver was investigated in rats. One group of animals received intravenous infusion of GIK continuously for 3 days, and two other groups of rats were given the same amount of saline intravenously. The animals receiving GIK, and a control group of the rats, were fasted for 8 h before sacrifice, while a second control group of animals was given free access to water and pellets until sacrifice. The heart, rectus femoris muscle and liver were then analysed for glycogen contents. It was found that fasting caused a depletion of glycogen in skeletal muscle and liver, while it did not cause any changes in myocardial glycogen which remained similar to that in the fed animals. Infusion of GIK prevented the depletion of glycogen in skeletal muscle and liver, but, unexpectedly, it did not cause any significant changes in myocardial glycogen content.
研究了静脉输注葡萄糖、胰岛素和钾（GIK）对大鼠心脏、骨骼肌和肝脏糖原含量的影响。一组动物连续3天静脉输注GIK，另外两组大鼠静脉注射等量生理盐水。接受GIK的动物以及一组对照大鼠在处死前禁食8小时，而另一组对照动物在处死前可自由饮水和进食颗粒饲料。然后分析心脏、股直肌和肝脏的糖原含量。结果发现，禁食导致骨骼肌和肝脏中的糖原耗竭，而心肌糖原没有发生任何变化，仍与喂食动物的心肌糖原相似。输注GIK可防止骨骼肌和肝脏中的糖原耗竭，但出乎意料的是，它并未引起心肌糖原含量的任何显著变化。
