Department of Clinical Medicine, China Medical University , Liaoning, Shenyang, China.
Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University , Liaoning, Shenyang, China.
Cell Adh Migr. 2020 Dec;14(1):165-181. doi: 10.1080/19336918.2020.1817251.
The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion through its deintegrin domain, which is closely related to tumor invasion and metastasis. It is widely expressed in a variety of tumor cells and can affect the proliferation, invasion and metastasis of related cancer cells. We provide our views on current progress, its increasing importance as a strategic treatment goal, and our vision for the future of ADAM9.
ADAMs 家族属于锌依赖型金属蛋白酶跨膜蛋白超家族，由多个结构域组成。这些结构域具有独立但互补的功能，使其能够参与多种生物学过程。其中，ADAM9 不仅可以作为金属蛋白酶参与细胞外基质的降解，还可以通过其解整合素结构域介导肿瘤细胞黏附，与肿瘤的侵袭和转移密切相关。ADAM9 在多种肿瘤细胞中广泛表达，可影响相关癌细胞的增殖、侵袭和转移。我们就 ADAM9 的研究现状、作为一个重要的治疗靶点的意义以及未来展望进行综述。
