Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey.
Department of Oral and Maxillofacial Surgery, Dental School, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran.
Cell Commun Signal. 2023 Jan 30;21(1):26. doi: 10.1186/s12964-022-01019-7.
MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological processes such as cell proliferation, apoptosis, autophagy, and migration. Deregulated levels of miR-20b contribute to the early- and advanced stages of cancer. On the other hand, investigations emphasize the tumor suppressor ability of miR-20b. High-throughput strategies are developed to identify miR-20b potential targets, providing the proper insight into its molecular mechanism of action. Moreover, accumulated results suggest that miR-20b exerts its effects through diverse signaling pathways, including PI3K/AKT/mTOR and ERK axes. Restoration of the altered expression levels of miR-20b induces cell apoptosis and reduces invasion and migration. Further, miR-20b can be used as a biomarker in cancer. The current comprehensive review could lead to a better understanding of the miR-20b in either tumorigenesis or tumor regression that may open new avenues for cancer treatment. Video Abstract.
MicroRNAs 作为非编码转录物，在正常生理条件下通过 RNA 沉默调节基因表达。它们的异常表达与肿瘤发生和癌症发展密切相关。miR-20b 是调节细胞增殖、凋亡、自噬和迁移等重要生物学过程的关键 miRNA 之一。miR-20b 水平的失调导致癌症的早期和晚期阶段。另一方面，研究强调了 miR-20b 的肿瘤抑制能力。已经开发了高通量策略来识别 miR-20b 的潜在靶标，为其作用的分子机制提供了正确的见解。此外，积累的结果表明，miR-20b 通过多种信号通路发挥作用，包括 PI3K/AKT/mTOR 和 ERK 轴。恢复 miR-20b 的改变表达水平可诱导细胞凋亡并减少侵袭和迁移。此外，miR-20b 可以用作癌症的生物标志物。本综述可以更好地理解 miR-20b 在肿瘤发生或肿瘤消退中的作用，这可能为癌症治疗开辟新的途径。视频摘要。
