Andrade Keitty Regina Cordeiro de, Carvalho Viviane Karoline da Silva, Farinasso Cecília Menezes, Lima Aurelina Aguiar de, Silva Roberta Borges, Wachira Virginia Kagure, Capucho Helaine Carneiro, Souza Patricia Medeiros de, Vanni Tazio, Sachetti Camile Giaretta, Rêgo Daniela Fortunato
Departamento de Ciência e Tecnologia, Ministério da Saúde, Brasília, DF, Brazil,
Departamento de Farmácia, Universidade de Brasilia, Brasília, DF, Brazil.
Cien Saude Colet. 2020 Sep;25(9):3517-3554. doi: 10.1590/1413-81232020259.14242020. Epub 2020 Aug 28.
This work aimed to evaluate the effects of drug therapies for coronavirus infections. Rapid systematic review with search in the MEDLINE, EMBASE, Cochrane, BVS, Global Index Medicus, Medrix, bioRxiv, Clinicaltrials.gov and International Clinical Trials Registry Platform databases. Thirty-six studies evaluating alternative drugs against SARS, SARS-CoV-2 and MERS were included. Most of the included studies were conducted in China with an observational design for the treatment of COVID-19. The most studied treatments were with antimalarials and antivirals. In antimalarial, the meta-analysis of two studies with 180 participants did not identify the benefit of hydroxychloroquine concerning the negative viral load via real-time polymerase chain reaction, and the use of antivirals compared to standard care was similar regarding outcomes. The available scientific evidence is preliminary and of low methodological quality, which suggests caution when interpreting its results. Research that evaluates comparative efficacy in randomized, controlled clinical trials, with adequate follow-up time and with the methods properly disclosed and subject to scientific peer review is required. A periodic update of this review is recommended.
这项工作旨在评估药物疗法对冠状病毒感染的影响。通过检索MEDLINE、EMBASE、Cochrane、BVS、全球医学索引、Medrix、bioRxiv、Clinicaltrials.gov和国际临床试验注册平台数据库进行快速系统评价。纳入了36项评估针对严重急性呼吸综合征（SARS）、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和中东呼吸综合征（MERS）的替代药物的研究。大多数纳入研究在中国进行，采用观察性设计治疗新型冠状病毒肺炎（COVID-19）。研究最多的治疗方法是使用抗疟药和抗病毒药物。在抗疟药方面，对两项涉及180名参与者的研究进行的荟萃分析未发现羟氯喹在通过实时聚合酶链反应检测病毒载量转阴方面的益处，并且与标准治疗相比，使用抗病毒药物的结局相似。现有的科学证据是初步的，方法学质量较低，这表明在解释其结果时需谨慎。需要开展在随机对照临床试验中评估比较疗效、有足够随访时间、方法充分披露且经过科学同行评审的研究。建议定期更新本综述。
