Lose G, Rix P, Diernaes E, Alexander N
Department of Obstetrics and Gynaecology, Kolding Hospital, Denmark.
Urol Int. 1988;43(1):11-5. doi: 10.1159/000281294.
Forty-four consecutive patients with genuine stress incontinence were treated with norfenefrine 15-30 mg t.i.d. in a 6-week, double-blind and parallel, placebo-controlled study. Subjectively, 52% were improved and 26% became continent during norfenefrine treatment. Objectively (stress test), 30% became continent and the maximum urethral closure pressure increased 10% which was statistically significant. These results, however, were not statistically different from those of placebo treatment. Simultaneously, subjective and objective improvement was seen more often in patients given norfenefrine compared to placebo (p less than 0.1). In patients with most severe incontinence according to urodynamic criteria the effect of norfenefrine was statistically significantly better than placebo. A low incidence of side effects was observed and no differences between norfenefrine and placebo were found. It is concluded that norfenefrine may be of value in the treatment of female stress incontinence.
在一项为期6周的双盲平行安慰剂对照研究中，对44例连续性真正压力性尿失禁患者给予去甲麻黄碱15 - 30毫克，每日3次治疗。主观上，在去甲麻黄碱治疗期间，52%的患者病情改善，26%的患者实现控尿。客观上（压力试验），30%的患者实现控尿，最大尿道闭合压增加10%，具有统计学意义。然而，这些结果与安慰剂治疗的结果在统计学上并无差异。同时，与安慰剂相比，接受去甲麻黄碱治疗的患者主观和客观改善更为常见（p小于0.1）。根据尿动力学标准，在最严重尿失禁的患者中，去甲麻黄碱的效果在统计学上显著优于安慰剂。观察到副作用发生率较低，且未发现去甲麻黄碱与安慰剂之间存在差异。结论是，去甲麻黄碱在女性压力性尿失禁的治疗中可能具有价值。
