Jørgensen L, Lose G, Alexander N
Department of Urology, Rigshospitalet, University of Copenhagen, Denmark.
Urol Int. 1991;46(2):176-9. doi: 10.1159/000282127.
To study the acute effect of norfenefrine, given orally in aqueous solution, on the urethral closure function, profilometry was performed before and after administration of placebo and increasing doses of norfenefrine in 6 females with genuine stress incontinence. A weak increase in urethral pressure was observed after administration of 90 mg of norfenefrine. No changes in heart rate and blood pressure occurred. The results indicate that the direct sympathomimetic effect of norfenefrine is weak. It is suggested that norfenefrine mainly acts via indirect mechanisms.
为研究口服水溶液去甲麻黄碱对尿道闭合功能的急性影响，对6名真性压力性尿失禁女性在服用安慰剂及递增剂量的去甲麻黄碱前后进行了压力测定。服用90毫克去甲麻黄碱后观察到尿道压力有微弱升高。心率和血压未发生变化。结果表明去甲麻黄碱的直接拟交感神经作用较弱。提示去甲麻黄碱主要通过间接机制起作用。
