Cassidy M J, Beck R M
Department of Medicine, University of Cape Town, South Africa.
Am J Kidney Dis. 1988 Jun;11(6):468-72. doi: 10.1016/s0272-6386(88)80081-7.
Renal function in 12 live kidney donors who had donated a kidney to a relative 3 to 10 years previously was studied. No clinically significant impairment of renal function was observed in the group. A significant rise in creatinine clearance (P = less than 0.01) occurred after a meat-protein load. When compared with 12 healthy controls with two kidneys, there was no significant difference in the percentage change in clearance after the meat load. In both groups there was an inverse correlation between the percentage change in creatinine clearance and the baseline creatinine clearance (P = less than 0.01), with no significant difference in the regression lines of the two groups. In conclusion, it appears that the single kidney responds appropriately to a meat-protein load and that there is no evidence from this study to suggest that hyperfiltration damaged the remaining kidney.
对12名在3至10年前将肾脏捐献给亲属的活体肾脏捐献者的肾功能进行了研究。该组未观察到具有临床意义的肾功能损害。摄入肉类蛋白质后，肌酐清除率显著升高（P＜0.01）。与12名拥有两个肾脏的健康对照者相比，摄入肉类后清除率的百分比变化无显著差异。两组中，肌酐清除率的百分比变化与基线肌酐清除率之间均呈负相关（P＜0.01），两组的回归线无显著差异。总之，似乎单个肾脏对肉类蛋白质负荷反应正常，且本研究没有证据表明超滤会损害剩余的肾脏。
