Chan M K
Aust N Z J Med. 1986 Oct;16(5):691-4. doi: 10.1111/j.1445-5994.1986.tb00014.x.
Renal response to a 60 g protein load was investigated in 33 normal subjects in terms of creatinine clearance and urinary protein excretion. The test was repeated in 10 of these subjects six months after donor nephrectomy. Creatinine clearance and urinary protein excretion increased significantly one and two hours after ingestion of the protein load (in the form of casein mixture); the change in urinary protein excretion correlated significantly with the change in creatinine clearance (p less than 0.0001). Plasma urea, calcium, and phosphate concentrations increased after protein ingestion, while plasma creatinine and uric acid decreased. Six months after donor nephrectomy the creatinine clearance had decreased but baseline protein excretion had increased. The pre-nephrectomy renal response to protein ingestion (i.e. increase in creatinine clearance and urinary protein excretion) did not predict creatinine clearance of the kidney after donor nephrectomy. After donor nephrectomy, the single kidney was able to increase creatinine clearance after a protein load, although qualitatively the response was different from that obtained with two kidneys in situ.
通过肌酐清除率和尿蛋白排泄情况，对33名正常受试者肾脏对60克蛋白质负荷的反应进行了研究。其中10名受试者在供体肾切除术后6个月重复了该测试。摄入蛋白质负荷（酪蛋白混合物形式）后1小时和2小时，肌酐清除率和尿蛋白排泄显著增加；尿蛋白排泄的变化与肌酐清除率的变化显著相关（p小于0.0001）。摄入蛋白质后，血浆尿素、钙和磷酸盐浓度升高，而血浆肌酐和尿酸降低。供体肾切除术后6个月，肌酐清除率下降，但基线蛋白排泄增加。肾切除术前肾脏对蛋白质摄入的反应（即肌酐清除率和尿蛋白排泄增加）并不能预测供体肾切除术后肾脏的肌酐清除率。供体肾切除术后，单肾在蛋白质负荷后能够增加肌酐清除率，尽管从质量上看，其反应与双肾原位时不同。
