Tanaka Yusuke, Ooike Michio, Watanabe Kenichi, Horiuchi Noriyuki, Kobayashi Yoshiyasu
Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Ooike Animal Hospital, Minami 5-46-21, Nishi 19, Obihiro, Hokkaido 080-8555, Japan.
J Vet Med Sci. 2020 Oct 20;82(10):1506-1510. doi: 10.1292/jvms.20-0391. Epub 2020 Sep 1.
A 97-day-old male Japanese domestic cat was diagnosed as congenital hypothyroidism. During the treatment, continuous hypercalcemia was detected. Although fluid therapy was performed, the cat died at the age of 1785 days. At autopsy, both parathyroid glands were enlarged, and elastic arterial walls were increased in thickness and hardness. Histopathological examination revealed hyperplasia of both parathyroid glands and interstitial fibrosis of bilateral kidneys. Severe calcification of the tunica media and tunica externa in systemic elastic and muscular arteries were also observed. These calcifications were considered to be due to renal secondary hyperparathyroidism. In the present case, hypothyroidism might have caused hyperparathyroidism through renal failure. In veterinary medicine, this is the first reported case of hypothyroidism accompanied with hyperparathyroidism.
一只97日龄的雄性日本家猫被诊断为先天性甲状腺功能减退。在治疗过程中，检测到持续性高钙血症。尽管进行了液体疗法，但这只猫在1785日龄时死亡。尸检时，双侧甲状旁腺均肿大，弹性动脉壁厚度和硬度增加。组织病理学检查显示双侧甲状旁腺增生以及双侧肾脏间质纤维化。还观察到全身弹性和肌性动脉的中膜和外膜严重钙化。这些钙化被认为是由于肾性继发性甲状旁腺功能亢进所致。在本病例中，甲状腺功能减退可能通过肾衰竭导致了甲状旁腺功能亢进。在兽医学中，这是首次报道的伴有甲状旁腺功能亢进的甲状腺功能减退病例。
