Sharafi Seyedeh Maryam, Mahdavi Manijeh, Riahi Roya, Kheirollahi Majid, Kelishadi Roya
Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Glob Med Genet. 2020 Jun;7(1):8-13. doi: 10.1055/s-0040-1710548. Epub 2020 Jul 9.
Polymorphisms in the C-reactive protein (CRP) genes might have crucial role in the development of metabolic syndrome (MetS). In the current comprehensive meta-analyses, we aim to provide a quantitative assessment of the association between CRP single-nucleotide polymorphisms (SNPs) and the risk of MetS. An electronic search was performed on several databases. After data extraction, random effect model was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Four independent studies including case-control, cohort, and cross-sectional methods were analyzed. Our meta-analysis indicated that CRP polymorphisms are not significantly associated with MetS (OR = 0.92, 95% CI = 0.77-1.10) with significant heterogeneity ( = 55.4%; -value = 0.008). The subgroup analysis revealed that only GG has significant association with MetS (OR = 0.32, 95% CI = 0.13-0.80, -value = 0.015) without significant heterogeneity ( = 0%, -value > 0.05). In conclusion, this meta-analysis provides strong evidence that only some SNPs of CRP gene are associated with the risk for development of MetS; and this relationship does not exist in different ethnic populations.
C反应蛋白（CRP）基因多态性可能在代谢综合征（MetS）的发生发展中起关键作用。在当前的综合荟萃分析中，我们旨在对CRP单核苷酸多态性（SNP）与MetS风险之间的关联进行定量评估。在多个数据库中进行了电子检索。数据提取后，使用随机效应模型计算合并比值比（OR）和95%置信区间（CI）。分析了四项包括病例对照、队列和横断面方法的独立研究。我们的荟萃分析表明，CRP多态性与MetS无显著关联（OR = 0.92，95%CI = 0.77 - 1.10），具有显著异质性（I² = 55.4%；P值 = 0.008）。亚组分析显示，只有GG与MetS有显著关联（OR = 0.32，95%CI = 0.13 - 0.80，P值 = 0.015），无显著异质性（I² = 0%，P值 > 0.05）。总之，这项荟萃分析提供了有力证据，表明只有CRP基因的某些SNP与MetS发生风险相关；且这种关系在不同种族人群中不存在。
