Karamzad Nahid, Izadi Neda, Sanaie Sarvin, Ahmadian Elham, Eftekhari Aziz, Sullman Mark J M, Safiri Saeid
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cardiovasc Thorac Res. 2020;12(2):120-128. doi: 10.34172/jcvtr.2020.20. Epub 2020 May 31.
This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS. The Web of Science, Medline, Scopus, Embase and Google Scholar were searched using the "Asthma", "Metabolic Syndrome", "Dysmetabolic Syndrome", "Cardiovascular Syndrome", "Insulin Resistance Syndrome", "Prevalence", "Odds Ratio", "Cross-Sectional Studies", and "Case-Control Studies" keywords. All observational studies reporting the prevalence of MetS among people with and without asthma were included in the study. In the presence of heterogeneity, random-effects models were used to pool the prevalence and odds ratios (OR), as measures of association in cross-sectional and case-control/ cohort studies, respectively. The prevalence of MetS among patients with asthma (8 studies) and the OR comparing the prevalence of MetS among patients with and without asthma (5 studies) were pooled separately. The pooled prevalence of MetS among patients with asthma was found to be 25% (95% confidence interval (CI): 13%-38%). In contrast, the overall pooled OR for MetS in patients with asthma, compared to healthy controls, was 1.34 (95% CI: 0.91-1.76), which was not statistically significant. The prevalence of MetS was relatively high in patients with asthma. Furthermore, the odds of MetS was higher in patients with asthma, compared to healthy controls, although this difference was not statistically significant. More original studies among different populations are needed in order to more accurately examine the association between asthma and MetS, as well as the relationship asthma has with the individual components of MetS.
本研究旨在对哮喘患者中代谢综合征（MetS）的患病率进行荟萃分析，并衡量哮喘与MetS之间的关联。使用关键词“Asthma”（哮喘）、“Metabolic Syndrome”（代谢综合征）、“Dysmetabolic Syndrome”（代谢紊乱综合征）、“Cardiovascular Syndrome”（心血管综合征）、“Insulin Resistance Syndrome”（胰岛素抵抗综合征）、“Prevalence”（患病率）、“Odds Ratio”（比值比）、“Cross-Sectional Studies”（横断面研究）和“Case-Control Studies”（病例对照研究）对Web of Science、Medline、Scopus、Embase和谷歌学术进行了检索。所有报告了有或无哮喘人群中MetS患病率的观察性研究均纳入本研究。在存在异质性的情况下，分别使用随机效应模型汇总患病率和比值比（OR），作为横断面研究和病例对照/队列研究中关联的衡量指标。分别汇总了哮喘患者中MetS的患病率（8项研究）以及比较有或无哮喘患者中MetS患病率的OR（5项研究）。结果发现，哮喘患者中MetS的合并患病率为25%（95%置信区间（CI）：13% - 38%）。相比之下，与健康对照相比，哮喘患者中MetS的总体合并OR为1.34（95% CI：0.91 - 1.76），差异无统计学意义。哮喘患者中MetS的患病率相对较高。此外，与健康对照相比，哮喘患者患MetS的几率更高，尽管这种差异无统计学意义。为了更准确地研究哮喘与MetS之间的关联以及哮喘与MetS各个组成部分之间的关系，需要在不同人群中开展更多的原始研究。
