Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Pharmacol Rep. 2020 Oct;72(5):1101-1124. doi: 10.1007/s43440-020-00156-5. Epub 2020 Sep 2.
STATs constitute a large family of transcription activators and transducers of signals that have an important role in many cell functions as regulation of proliferation and differentiation of the cell also regulation of apoptosis and angiogenesis. STAT3 as a member of that family, recently was discovered to have a vital role in progression of different types of cancers. The activation of STAT3 was observed to regulate multiple gene functions during cancer-like cell proliferation, differentiation, apoptosis, metastasis, inflammation, immunity, cell survival, and angiogenesis. The inhibition of STAT3 activation has been an important target for cancer therapy. Inhibitors of STAT3 have been used for a long time for treatment of many types of cancers like leukemia, melanoma, colon, and renal cancer. In this review article, we summarize and discuss different drugs inhibiting the action of STAT3 and used in treatment of different types of cancer.
STATs 构成了转录激活因子和信号转导因子的大家族，它们在许多细胞功能中起着重要作用，如调节细胞的增殖和分化，以及细胞凋亡和血管生成。STAT3 作为该家族的一员，最近被发现在不同类型癌症的进展中起着至关重要的作用。研究发现，STAT3 的激活调节了类似癌细胞增殖、分化、凋亡、转移、炎症、免疫、细胞存活和血管生成过程中的多种基因功能。抑制 STAT3 的激活已成为癌症治疗的一个重要目标。STAT3 的抑制剂已被长期用于治疗多种类型的癌症，如白血病、黑色素瘤、结肠癌和肾癌。在这篇综述文章中，我们总结和讨论了不同的药物抑制 STAT3 的作用，并用于治疗不同类型的癌症。
