Romera Luís Felipe, Schuh Luísa, Leal Caio, Chang Leonardo Froes de Azevedo, Santos Brenda Martins Dos, da Rocha Pedro Henrique Almeida de Jesus, Radicchi Marina Arantes, Gris Eliana Fortes, Falcao Leila, Báo Sônia Nair, Mello Victor Carlos
Cooil Cosmetics, Brasília 72622-401, DF, Brazil.
Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.
Int J Mol Sci. 2025 Aug 28;26(17):8373. doi: 10.3390/ijms26178373.
Plant-derived compounds offer immense therapeutic potential, yet many suffer from limited solubility, instability, and poor bioavailability, restricting their clinical application. Curcumin, a polyphenol extracted from , is one such molecule, with proven antioxidant and anti-inflammatory properties. To overcome its pharmacokinetic limitations, we developed Jamamina, a sustainable nanostructured lipid carrier (NLC) system incorporating curcumin and a Natural Deep Eutectic Solvent (NaDES) phase composed of malic acid and betaine. The bioinspired formulation, based on Amazonian tucumã butter and jambu oil, achieved high encapsulation efficiency (>80%) and curcumin amorphization, enhancing solubility and colloidal stability. In vitro assays with L132 demonstrated potent antioxidant activity (DPPH), a significant reduction in pro-inflammatory cytokines (TNF-α and IL-6), and upregulation of IL-10. The system also suppressed MMP-2/9 activity and preserved cytoskeletal integrity under oxidative stress. These findings highlight Jamamina as a multifunctional, eco-friendly nanoplatform that enables the pharmacological application of plant-derived curcumin, representing a promising platform for modulating redox balance and investigating inflammation in epithelial-like contexts.
植物源化合物具有巨大的治疗潜力，但许多化合物存在溶解度有限、稳定性差和生物利用度低的问题，限制了它们的临床应用。姜黄素是一种从……中提取的多酚，就是这样一种分子，具有已被证实的抗氧化和抗炎特性。为了克服其药代动力学限制，我们开发了Jamamina，这是一种可持续的纳米结构脂质载体（NLC）系统，包含姜黄素和由苹果酸和甜菜碱组成的天然低共熔溶剂（NaDES）相。这种受生物启发的制剂基于亚马逊图康脂和展凤果油，实现了高包封率（>80%）和姜黄素非晶化，提高了溶解度和胶体稳定性。用L132进行的体外试验显示出强大的抗氧化活性（DPPH），促炎细胞因子（TNF-α和IL-6）显著减少，以及IL-10上调。该系统还在氧化应激下抑制MMP-2/9活性并保持细胞骨架完整性。这些发现突出了Jamamina作为一种多功能、生态友好的纳米平台，能够实现植物源姜黄素的药理学应用，代表了一个在类似上皮环境中调节氧化还原平衡和研究炎症的有前景的平台。
