埃及代谢综合征男性样本中血清睾酮与鸢尾素水平的相关性；（病例对照研究）
Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study).
作者信息
Ahmad Inass Hassan, Mohamed Mostafa Eman Roshdy, Mohammed Shymaa Abdelhafeez, Shipl Walaa, Soliman Amany Ahmed, Said Marwa
机构信息
Endocrinology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Internal Medicine Department, faculty of medicine (for Girls), Al-Azhar University, Cairo, Egypt.
出版信息
Arch Physiol Biochem. 2023 Feb;129(1):180-185. doi: 10.1080/13813455.2020.1808018. Epub 2020 Sep 3.
BACKGROUND
Metabolic syndrome (MetS) in men is a common problem. Several studies highlight that testosterone deficiency is associated with metabolic disorders that may be explained by "myokines". Irisin is an adipo-myokine that has beneficial metabolic effects.
AIM
To evaluate serum testosterone in a sample of Egyptian men with MetS diagnosed by NCEP ATP III, and correlate it with serum irisin level.
METHODS
A total of 90 men (60 with MetS and 30 healthy age-matched controls) participated in the study. Testosterone level is estimated by an automated system, Irisin level was measured by ELISA.
RESULTS
Circulating irisin was positively correlated with serum testosterone and was significantly lower in patients with MetS.
CONCLUSION
This study highlights the effect of serum testosterone on irisin formation from skeletal muscle. Recommendations treatments of MetS may include testosterone supplementation. Further studies are needed to elucidate this association.
背景
男性代谢综合征（MetS）是一个常见问题。多项研究强调，睾酮缺乏与可能由“肌动蛋白”解释的代谢紊乱有关。鸢尾素是一种具有有益代谢作用的脂肪肌动蛋白。
目的
评估通过美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）诊断的埃及男性代谢综合征患者样本中的血清睾酮水平，并将其与血清鸢尾素水平相关联。
方法
共有90名男性（60名代谢综合征患者和30名年龄匹配的健康对照者）参与了该研究。睾酮水平通过自动化系统估算，鸢尾素水平通过酶联免疫吸附测定（ELISA）测量。
结果
循环鸢尾素与血清睾酮呈正相关，且在代谢综合征患者中显著降低。
结论
本研究强调了血清睾酮对骨骼肌中鸢尾素形成的影响。代谢综合征的推荐治疗方法可能包括补充睾酮。需要进一步研究以阐明这种关联。
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