Ragab Ahmed, Sayed Ahmed Reda, GamalEl Din Sameh Fayek, Zeidan Ashraf, Ewis Faten Fathi, Hamed Mostafa Ahmed
Department of Andrology, Sexology and STDs, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Diabetol Metab Syndr. 2024 Sep 19;16(1):233. doi: 10.1186/s13098-024-01452-3.
Irisin is an exercise-induced myokine that alleviates endothelial dysfunction and reduces insulin resistance in type 2 diabetes mellitus (T2DM). The current study aimed to assess the serum level of irisin in T2DM men with erectile dysfunction (ED) compared to T2DM patients with normal erectile function and healthy controls, as well as investigate the association between serum irisin level and the severity of ED in T2DM patients.
A cross-sectional study was conducted on 90 males, divided into three groups: 32 T2DM patients with ED, 24 T2DM patients without ED, and 34 healthy controls. Socio-demographic characteristics and scores of the validated Arabic version of the international Index of Erectile Function-5 (ArIIEF-5), Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) were obtained. Furthermore, routine laboratory tests employed for diabetes monitoring and serum levels of total testosterone and irisin were assessed within these groups.
T2DM men with ED had significantly lower serum levels of irisin and testosterone, as well as a lower ArIIEF-5 score, but their GAD-7 and PHQ-9 scores were significantly higher than those without ED or controls (p < 0.001). Among T2DM men, serum irisin levels positively associated with ArIIEF-5 scores and serum testosterone (r = 0.413, p = 0.002; r = 0.936, p < 0.001, respectively) but negatively associated with glycosylated hemoglobin levels (r = -0.377, p = 0.004). Multivariate regression analysis to predict ED in T2DM patients found that GAD-7 score was the only most significant predictor for ED (ꞵ = - 1.176, standard error = 0.062, p < 0.001).
The current study had demonstrated that irisin positively correlated with the ArIIEF-5 and serum testosterone but negatively correlated with HbA1c in T2DM men. Nevertheless, further validation of these findings is necessary through cohort studies.
鸢尾素是一种运动诱导的肌动蛋白，可减轻2型糖尿病（T2DM）患者的内皮功能障碍并降低胰岛素抵抗。本研究旨在评估伴有勃起功能障碍（ED）的T2DM男性患者与勃起功能正常的T2DM患者及健康对照者的血清鸢尾素水平，并探讨T2DM患者血清鸢尾素水平与ED严重程度之间的关联。
对90名男性进行了一项横断面研究，分为三组：32例伴有ED的T2DM患者、24例不伴有ED的T2DM患者和34名健康对照者。获取了社会人口学特征以及经过验证的阿拉伯语版国际勃起功能指数-5（ArIIEF-5）、广泛性焦虑障碍-7（GAD-7）和患者健康问卷-9（PHQ-9）的评分。此外，还评估了这些组内用于糖尿病监测的常规实验室检查以及总睾酮和鸢尾素的血清水平。
伴有ED的T2DM男性患者的血清鸢尾素和睾酮水平显著较低，ArIIEF-5评分也较低，但他们的GAD-7和PHQ-9评分显著高于不伴有ED的患者或对照组（p < 0.001）。在T2DM男性患者中，血清鸢尾素水平与ArIIEF-5评分和血清睾酮呈正相关（r = 0.413，p = 0.002；r = 0.936，p < 0.001），但与糖化血红蛋白水平呈负相关（r = -0.377，p = 0.004）。预测T2DM患者ED的多因素回归分析发现，GAD-7评分是ED唯一最显著的预测因素（β = -1.176，标准误 = 0.062，p < 0.001）。
本研究表明，鸢尾素与T2DM男性患者的ArIIEF-5和血清睾酮呈正相关，但与糖化血红蛋白呈负相关。然而，有必要通过队列研究对这些发现进行进一步验证。
