Departments of, Department of, Dermatology, Toyonaka Municipal Hospital, Toyonaka, Japan.
Department of, Neurology, Toyonaka Municipal Hospital, Toyonaka, Japan.
J Dermatol. 2020 Oct;47(10):1175-1178. doi: 10.1111/1346-8138.15532. Epub 2020 Aug 17.
Individuals infected with the novel coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) who develop coronavirus disease 2019 (COVID-19) experience many symptoms; however, cutaneous manifestations are relatively rare. The authors encountered three patients with COVID-19 who presented with erythema and suspected viral rash. In all cases, erythema appeared after the onset of the initial symptoms of COVID-19. Erythema was considered to be caused by COVID-19 and not a drug-induced eruption because, in all cases, erythema was relieved merely by external medicine and oral antihistamines, without discontinuing the original medication. The authors' hospital accepted 69 COVID-19 patients between 22 February 2020 and 31 May 2020 and, of these, three (4.3%) exhibited eruptions, and all cases presented erythema. Except for seven patients who exhibited positive nasopharyngeal swab tests for SARS-CoV-2 RNA but no symptoms, three (4.8%) of the remaining 62 patients exhibited erythema. Although various types of eruptions have been reported in patients with COVID-19, erythema was the only type in our patients. Erythema in the three patients exhibited many similarities to that previously reported in COVID-19 patients, particularly in the manner it appeared and disappeared. For these reasons, these three cases were considered typical examples of erythema in patients with COVID-19. Considering previous studies and the three cases reported here, there is a high probability that SARS-CoV-2 can cause erythema.
个体感染新型冠状病毒（严重急性呼吸综合征冠状病毒 2[SARS-CoV-2]）并发展为 2019 冠状病毒病（COVID-19）时会出现许多症状，但皮肤表现相对较少见。作者遇到了 3 名 COVID-19 患者，他们出现红斑和疑似病毒性皮疹。在所有情况下，红斑出现在 COVID-19 初始症状出现之后。红斑被认为是由 COVID-19 引起的，而不是药物引起的皮疹，因为在所有情况下，红斑仅通过外用药和口服抗组胺药缓解，而无需停用原始药物。作者的医院在 2020 年 2 月 22 日至 5 月 31 日期间共收治了 69 名 COVID-19 患者，其中 3 名（4.3%）出现皮疹，所有病例均表现为红斑。除了 7 名鼻咽拭子 SARS-CoV-2 RNA 检测呈阳性但无症状的患者外，其余 62 名患者中有 3 名（4.8%）出现红斑。尽管 COVID-19 患者报告了各种类型的皮疹，但在我们的患者中，只有红斑。这 3 名患者的红斑与之前报道的 COVID-19 患者的红斑有许多相似之处，尤其是其出现和消失的方式。基于这些原因，这 3 例被认为是 COVID-19 患者红斑的典型病例。考虑到之前的研究和这里报告的 3 例，SARS-CoV-2 极有可能引起红斑。
