Bryzgalova T E, Tsibanov V V, Nekliudov A D, Bartoshevich Iu E
Antibiot Khimioter. 1988 Jan;33(1):26-30.
A laboratory unit for production of calcium alginate gel granules with immobilized microorganisms is described. It provides sterile production of particles from tens micrometers to 2 mm in diameter. Expediency of using biocatalysts in the form of fine granules is exemplified with a number of immobilized microorganisms. Conditions for immobilizing the erythromycin producing organism by its incorporation into the calcium alginate gel were studied. Viability of the actinomycete in the gel was shown by consumption of the nutrients and biosynthesis of the antibiotic.
描述了一种用于生产固定化微生物的海藻酸钙凝胶颗粒的实验室装置。它能无菌生产直径从几十微米到2毫米的颗粒。许多固定化微生物例证了使用细颗粒形式生物催化剂的便利性。研究了通过将红霉素生产菌掺入海藻酸钙凝胶中来固定化的条件。通过营养物质的消耗和抗生素的生物合成表明了放线菌在凝胶中的活力。