Sharifian Nastaran, Bahrami Samani Ehsan, Ganjali Mojtaba
Department of Statistics, Shahid Beheshti University, Tehran, Iran.
J Biopharm Stat. 2021 Mar;31(2):117-140. doi: 10.1080/10543406.2020.1814798. Epub 2020 Sep 3.
In this paper, a joint model is presented for analyzing longitudinal continuous and count mixed responses. The frequency distribution of continuous longitudinal response variable for each subject at any time has a skewed and or multi-modal form. Then, a suitable finite mixture of normals is used as its distribution. It seems that the continuous response comes from several distinct sub-populations. The number of zeros of the count response is inflated. Also, a zero-inflated power series (ZIPS) distribution is applied as its distribution in order to model the count response. The correlation of longitudinal responses through time and that of mixed continuous and count responses are modeled by utilizing the random-effects vectors in the finite mixtures of regression (FMR) models. Further, a full likelihood-based approach is used to obtain the maximum likelihood estimates of parameters via the EM algorithm. Then, some simulation studies are performed for assessing the performance of the model. Additionally, an application is illustrated for joint analysis of the number of days during the last month that the individual drank alcohol, as well as the respondents' weight. Finally, the two first times of the Americans Changing Lives survey are evaluated.
本文提出了一种联合模型,用于分析纵向连续和计数混合响应。每个受试者在任何时间的连续纵向响应变量的频率分布具有偏态和/或多峰形式。然后,使用合适的正态有限混合作为其分布。似乎连续响应来自几个不同的亚群体。计数响应的零值数量过多。此外,应用零膨胀幂级数(ZIPS)分布作为其分布来对计数响应进行建模。通过利用回归有限混合(FMR)模型中的随机效应向量,对纵向响应随时间的相关性以及连续和计数混合响应的相关性进行建模。此外,使用基于完全似然的方法通过期望最大化(EM)算法获得参数的最大似然估计。然后,进行了一些模拟研究以评估模型的性能。此外,还给出了一个应用示例,用于联合分析个体上个月饮酒的天数以及受访者的体重。最后,对“美国人生活变化”调查的前两次进行了评估。