Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Clinical Neuroscience Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
CNS Neurol Disord Drug Targets. 2020;19(6):466-477. doi: 10.2174/1871527319666200902133343.
The aim of this paper is to demonstrate the impact of hemodialysis (HD) using synthetic Helixone membrane on brain functional control reorganization and plasticity in the cortical area generated while Oxidative Stress (OS) would be the main impacting agent.
Indeed, 9 chronic HD patients underwent identical brain BOLD-fMRI assessment using the motor paradigm immediately before and after the same HD sessions. To assess the oxidative stress, the same patients underwent biological-assessment, including Malondialdehyde (MDA) and Total- Antioxidant-Activity (TAOA) reported in earlier papers.
BOLD-fMRI maps of motor areas obtained from HD-patients before and after HD sessions revealed a significant enhancement of activation volume of the studied motor cortex after HD reflecting brain plasticity. Results were correlated with OS assessed by the measurement of MDA and TAOA; this correlation was close to 1.
Indeed, HD enhances the inflammatory state of brain tissues reflected by the increased OS. The functional brain reaction demonstrated a functional activity reorganization to overcome the inflammatory state and OS enhanced by HD process. This functional activity reorganization reveals brain plasticity induced by OS originated by HD.
本文旨在展示使用合成 Helixone 膜进行血液透析 (HD) 对大脑功能控制重组和皮质区可塑性的影响，氧化应激 (OS) 将是主要影响因素。
实际上，9 名慢性 HD 患者在相同的 HD 治疗前后使用运动范式进行了相同的脑 BOLD-fMRI 评估。为了评估氧化应激，同一批患者进行了生物评估，包括以前的论文中报告的丙二醛 (MDA) 和总抗氧化活性 (TAOA)。
从 HD 治疗前后的 HD 患者获得的运动区的 BOLD-fMRI 图谱显示，HD 后研究运动皮层的激活体积显著增加，反映了大脑的可塑性。结果与通过 MDA 和 TAOA 测量评估的 OS 相关；这种相关性接近 1。
事实上，HD 增强了由 HD 过程增强的炎症状态。功能大脑反应表现出对炎症状态和 OS 的功能活动重新组织，以克服 HD 过程增强的炎症状态。这种功能活动重组揭示了由 OS 引起的大脑可塑性。
