Division of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia.
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
CNS Neurol Disord Drug Targets. 2020;19(10):725-740. doi: 10.2174/1871527319666200902134129.
1-Methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol, commonly known as salsolinol, is a compound derived from dopamine. It was first discovered in 1973 and has gained attention for its role in Parkinson's disease. Salsolinol and its derivatives were claimed to play a role in the pathogenesis of Parkinson's disease as a neurotoxin that induces apoptosis of dopaminergic neurons due to its structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its ability to induce Parkinsonism. In this article, we discussed the biosynthesis, distribution and blood-brain barrier permeability of salsolinol. The roles of salsolinol in a healthy brain, particularly the interactions with enzymes, hormone and catecholamine, were reviewed. Finally, we discussed the involvement of salsolinol and its derivatives in the pathogenesis of Parkinson's disease.
1-甲基-1,2,3,4-四氢异喹啉-6,7-二醇，通常称为萨洛林醇，是一种源自多巴胺的化合物。它于 1973 年首次被发现，因其在帕金森病中的作用而受到关注。萨洛林醇及其衍生物被认为在帕金森病的发病机制中发挥作用，作为一种神经毒素，由于其与 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的结构相似，并且能够诱导帕金森病，导致多巴胺能神经元凋亡。在本文中，我们讨论了萨洛林醇的生物合成、分布和血脑屏障通透性。还综述了萨洛林醇在健康大脑中的作用，特别是与酶、激素和儿茶酚胺的相互作用。最后，我们讨论了萨洛林醇及其衍生物在帕金森病发病机制中的参与。
