The Tony and Leona Campane Center for Excellence in Image-guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
PLoS One. 2020 Sep 3;15(9):e0237078. doi: 10.1371/journal.pone.0237078. eCollection 2020.
To investigate the association between outer retinal layer metrics, including photoreceptor outer segment volume, on spectral-domain optical coherence tomography (OCT) and brain volume on MRI in normal aging, Alzheimer's disease and Parkinson's disease.
This was an exploratory analysis of a cross-sectional cohort study that was approved by the Cleveland Clinic Institutional Review Board to evaluate neurodegenerative disorders. Subjects aged ≥ 50 were recruited. A comprehensive neurological exam, brain MRI with volumetric evaluation, and OCT were performed for each subject. Outer retinal layer parameters, including ellipsoid zone (EZ) to retinal pigment epithelium (RPE) volume (i.e., surrogate for panmacular photoreceptor outer segment volume), were evaluated with a novel OCT analysis platform.
Of 85 subjects, 64 eyes of 64 subjects met MRI and OCT quality control criteria. Total brain volume (%ICV) significantly correlated with EZ-RPE volume in the normal cognition control group (n = 31, Pearson correlation coefficient 0.514, P < .01), the Parkinson's disease group (n = 19, Pearson correlation coefficient 0.482, P = .04), and the Alzheimer's dementia group (n = 14, Pearson correlation coefficient 0.526, P = .05). Multiple linear regression analysis revealed that photoreceptor outer segment (i.e., EZ-RPE) volume was an independent, influential factor on total brain volume in all study subjects (Coefficient 15.2, 95% confidence interval 7.8-22.6, P < .001).
Outer retinal parameters on OCT may serve as a novel biomarker related to brain volume. This correlation was noted in control subjects suggesting a possible developmental link between retina and brain volume. This relationship was also maintained with atrophic neurodegenerative disorders. Further research is needed to explore possible threshold differences for underlying neurodegenerative disorders.
探究在正常衰老、阿尔茨海默病和帕金森病中，光谱域光学相干断层扫描（OCT）的外视网膜层测量值（包括光感受器外节体积）与磁共振成像（MRI）上的脑容量之间的关联。
这是一项横断面队列研究的探索性分析，该研究得到克利夫兰诊所机构审查委员会的批准，旨在评估神经退行性疾病。招募年龄≥50 岁的受试者。对每位受试者进行全面的神经学检查、脑 MRI 容积评估和 OCT。使用新型 OCT 分析平台评估外视网膜层参数，包括椭圆体带（EZ）到视网膜色素上皮（RPE）的体积（即全视网膜光感受器外节体积的替代指标）。
在 85 名受试者中，64 只眼的 MRI 和 OCT 质量控制符合标准。在正常认知对照组（n = 31，Pearson 相关系数 0.514，P <.01）、帕金森病组（n = 19，Pearson 相关系数 0.482，P =.04）和阿尔茨海默病痴呆组（n = 14，Pearson 相关系数 0.526，P =.05）中，总脑容量（%ICV）与 EZ-RPE 体积显著相关。多元线性回归分析显示，在外视网膜层（即 EZ-RPE）体积是所有研究对象总脑容量的独立影响因素（系数 15.2，95%置信区间 7.8-22.6，P <.001）。
OCT 上的外视网膜参数可能是与脑容量相关的新型生物标志物。在对照组中观察到这种相关性，提示视网膜和脑容量之间可能存在发育联系。这种相关性在萎缩性神经退行性疾病中也得到了维持。需要进一步研究来探索潜在神经退行性疾病的可能阈值差异。
