Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea.
Department of Laboratory Medicine, National Cancer Center, Goyang, South Korea.
J Clin Apher. 2021 Feb;36(1):28-33. doi: 10.1002/jca.21835. Epub 2020 Sep 3.
Autologous peripheral blood stem cell (PBSC) transplantation has become a standard treatment option for many oncology patients. The aim of this study was to evaluate the performance of two cell separators, Spectra Optia (Terumo BCT, Japan) and Amicus (Fresenius-Kabi) for autologous PBSC collection.
We retrospectively evaluated 56 apheresis by Spectra Optia with Continuous Mononuclear Cell Collection (cMNC) from 20 patients, and 50 apheresis by Amicus from 27 patients between December 2018 and December 2019. CD34+ collection efficiency (CE2) and platelet (PLT) loss were evaluated.
There was no significant difference in CD34+ CE2 between Spectra Optia with cMNC (median, 28.8%) and Amicus (median, 33.1%; P = 0.537). PLT loss was significantly lower in Amicus (median, 28.6%) than in Spectra Optia with cMNC (median, 37.8%; P = 0.009).
CD34+ CE2 was comparable between Spectra Optia and Amicus, and PLT loss was significantly lower in Amicus. To the best of our knowledge, this is the first report comparing autologous PBSC collection of the Spectra Optia and Amicus. These results may provide general guidance with regard to device selection to apheresis clinics that use both separators for optimal outcomes depending on each patient's characteristics.
自体外周血造血干细胞（PBSC）移植已成为许多肿瘤患者的标准治疗选择。本研究旨在评估两种细胞分离机，Spectra Optia（Terumo BCT，日本）和 Amicus（Fresenius-Kabi），在自体 PBSC 采集方面的性能。
我们回顾性评估了 2018 年 12 月至 2019 年 12 月期间 20 名患者的 56 次 Spectra Optia 连续单核细胞采集（cMNC）和 27 名患者的 50 次 Amicus 采集。评估了 CD34+采集效率（CE2）和血小板（PLT）丢失。
Spectra Optia 与 cMNC（中位数，28.8%）和 Amicus（中位数，33.1%；P = 0.537）之间的 CD34+CE2 无显著差异。Amicus 的 PLT 丢失明显低于 Spectra Optia 与 cMNC（中位数，28.6% vs. 37.8%；P = 0.009）。
Spectra Optia 与 Amicus 之间的 CD34+CE2 相当，Amicus 的 PLT 丢失明显较低。据我们所知，这是首次比较 Spectra Optia 和 Amicus 自体 PBSC 采集的报告。这些结果可能为根据每个患者的特点，为同时使用这两种分离机的采集中心提供设备选择方面的一般指导，以获得最佳结果。
