Morssinkhof M W L, van Wylick D W, Priester-Vink S, van der Werf Y D, den Heijer M, van den Heuvel O A, Broekman B F P
OLVG Hospital, Department of Psychiatry and Medical Psychology, P.O. Box 95500, 1090 HM, Amsterdam, The Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, The Netherlands; Amsterdam UMC, Vrije Universiteit van Amsterdam, Department of Endocrinology, De Boelelaan 1117, Amsterdam, The Netherlands.
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, The Netherlands.
Neurosci Biobehav Rev. 2020 Nov;118:669-680. doi: 10.1016/j.neubiorev.2020.08.006. Epub 2020 Aug 31.
Sleep problems and depression are both common and have a high impact on quality of life. They are also strongly associated and commonly occur together. During the reproductive age, both sleep problems and depression are almost twice as common in women than men. Epidemiological studies show that women experience more sleep problems and depressive symptoms around times when sex hormones change, such as puberty and menopause, but it is unclear what effect sex hormones have on sleep problems and depression. This systematic review aims to summarize and evaluate studies that investigated the relationship between sex hormones, sleep and depression. Systematic search resulted in 2895 articles, of which 13 met inclusion criteria. Depressed patients showed worse sleep than controls, but no significant difference in endogenous hormone levels was found. Additionally, higher endogenous estrogen was associated with better sleep in controls, but associations between endogenous sex hormones and depressive symptoms were inconclusive. More research on the effect of sex hormones on sleep and depression is necessary.
睡眠问题和抑郁症都很常见，且对生活质量有很大影响。它们之间也存在紧密关联，常常同时出现。在生育年龄阶段，女性出现睡眠问题和抑郁症的几率几乎是男性的两倍。流行病学研究表明，女性在诸如青春期和更年期等性激素发生变化的时期，会出现更多的睡眠问题和抑郁症状，但目前尚不清楚性激素对睡眠问题和抑郁症有何影响。本系统综述旨在总结和评估那些研究性激素、睡眠与抑郁症之间关系的研究。系统检索共得到2895篇文章，其中13篇符合纳入标准。抑郁症患者的睡眠状况比对照组更差，但未发现内源性激素水平存在显著差异。此外，较高的内源性雌激素与对照组较好的睡眠状况相关，但内源性性激素与抑郁症状之间的关联尚无定论。有必要对性激素对睡眠和抑郁症的影响进行更多研究。
