Cao Zhaoxing, Zhuo Fangfang, Yan Fei, Hu Xi, Xia Guiling, Huang Cheng, Lu Ting, Pu Zhipeng, Huang Runze, Chen Zhangrong
Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica University, Guiyang, 550004, China.
The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Sci Rep. 2025 Jul 7;15(1):24255. doi: 10.1038/s41598-025-09529-3.
Both hypertension and sleep disturbance have been closely linked to inflammation. However, the specific role of inflammation in the relationship between sleep disturbance and hypertension remains unclear. We investigated the pairwise associations among a novel inflammatory marker (systemic immune inflammation index ), sleep disturbance, and hypertension in a powerful, racially diverse sample (n = 23,414) from the 2005-2020 National Health and Nutrition Examination Survey (NHANES). We found that participants with high blood pressure and/or sleep disorders had higher levels of Systemic Immune-Inflammatory Index (SII) than those without hypertension or sleep disorders.SII slightly but significantly mediated the relationship between sleep disturbance and hypertension in males but not in females, after adjusting for all covariates (proportion mediate [PM], 1.36%; total effect [TE], 0.0931; direct effect [ADE], 0.0917; verage causal mediation effects [ACME] = 0.0013 [95% CI = 0.0004-0.0024], p = 0.002, in males. Our research showed that SII, sleep disturbance, and hypertension are related. Increased SII levels slightly mediated the association between sleep disturbance and hypertension.
高血压和睡眠障碍都与炎症密切相关。然而，炎症在睡眠障碍与高血压关系中的具体作用仍不清楚。我们在2005 - 2020年国家健康与营养检查调查（NHANES）中一个规模庞大、种族多样的样本（n = 23414）中，研究了一种新型炎症标志物（全身免疫炎症指数）、睡眠障碍和高血压之间的两两关联。我们发现，患有高血压和/或睡眠障碍的参与者的全身免疫炎症指数（SII）水平高于没有高血压或睡眠障碍的参与者。在调整所有协变量后，SII在男性中轻微但显著地介导了睡眠障碍与高血压之间的关系，而在女性中则不然（男性中介比例[PM]为1.36%；总效应[TE]为0.0931；直接效应[ADE]为0.0917；平均因果中介效应[ACME] = 0.0013 [95%置信区间 = 0.0004 - 0.0024]，p = 0.002）。我们的研究表明，SII、睡眠障碍和高血压之间存在关联。SII水平升高轻微介导了睡眠障碍与高血压之间的关联。
