Yang Changzhao, Lv Zhengtong, Li Yuan
Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Urol Int. 2021;105(1-2):155-158. doi: 10.1159/000510167. Epub 2020 Sep 3.
Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few such cases and corresponding treatments have been reported. We speculated that the tuberculosis infection existed, so antitubercular therapy was given. After a 3-month oral intake of rifampicin, isoniazid, and ofloxacin, the volume of bladder returned to normal and the voiding symptoms disappeared. This case indicated that the reduction of bladder volume caused by BCG instillation could be treated with antitubercular therapy. Prompt and accurate diagnosis was important for the management.
卡介苗（BCG）免疫疗法是原位癌和高危非肌肉浸润性膀胱癌（NMIBC）最有效的治疗方法。然而，它也可能引发多种副作用。我们发现1例患者在膀胱内灌注卡介苗后膀胱容量显著且迅速减少。此类病例及相应治疗报道较少。我们推测存在结核感染，因此给予抗结核治疗。口服利福平、异烟肼和氧氟沙星3个月后，膀胱容量恢复正常，排尿症状消失。该病例表明，卡介苗灌注引起的膀胱容量减少可用抗结核治疗。及时准确的诊断对治疗管理很重要。
