Zauli D, Gobbi M, Crespi C, Tazzari P L, Miserocchi F, Tassinari A
Istituto di Clinica Medica II, University of Bologna, Italy.
Br J Haematol. 1988 Apr;68(4):405-9. doi: 10.1111/j.1365-2141.1988.tb04226.x.
An anomalous organization of the cytoskeleton has been described in lymphocytes from chronic lymphatic leukaemia and in only few cell lines. We have now studied normal and neoplastic lymphocytes and lymphoid cell lines of both T and B lineage in order to detect morphological differences in the expression of microfilaments and intermediate filaments. Microfilaments appear to be well expressed by all the B cells, whereas a rich network of intermediate filaments is present in T cells and plasma cells. Most prominent changes occur in the latter system, which is almost lacking in cells of B chronic lymphatic and hairy cell leukaemia. Although the significance of the present findings is not yet clear, one might speculate that such alterations account for some of the aberrant functions and peculiar biologic properties of neoplastic lymphocytes.
慢性淋巴细胞白血病患者的淋巴细胞以及仅少数细胞系中已发现细胞骨架存在异常组织。我们现在研究了T和B谱系的正常及肿瘤性淋巴细胞和淋巴样细胞系，以检测微丝和中间丝表达的形态学差异。所有B细胞似乎都能很好地表达微丝，而T细胞和浆细胞中存在丰富的中间丝网络。最显著的变化发生在后一个系统中，B慢性淋巴细胞白血病和毛细胞白血病的细胞中几乎没有该系统。尽管目前这些发现的意义尚不清楚，但有人可能推测，这种改变是肿瘤性淋巴细胞一些异常功能和特殊生物学特性的原因。
