Novel Multitarget Therapies for Lung Cancer and Respiratory Disease.

In recent years, multitarget drugs for neurological diseases such as Alzheimer's disease have been developed and well researched. Many studies have revealed that multitarget drugs are also useful for lung cancer and respiratory diseases. Pemetrexed is a multitargeted antifolate with strong antitumor activity against mesothelioma and lung adenocarcinoma. Crizotinib is an ATP-competitive tyrosine kinase inhibitor that targets , and . Alectinib is known as an inhibitor but also targets , , , and . Sorafenib is a tyrosine kinase inhibitor that targets RAF kinase, , , , , and . Nintedanib is a multiple tyrosine kinase inhibitor that targets , and . In this review, we summarize the mechanisms of action of multitarget therapies and report the results of the latest clinical trials.