Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Molecules. 2020 Sep 1;25(17):3987. doi: 10.3390/molecules25173987.
In recent years, multitarget drugs for neurological diseases such as Alzheimer's disease have been developed and well researched. Many studies have revealed that multitarget drugs are also useful for lung cancer and respiratory diseases. Pemetrexed is a multitargeted antifolate with strong antitumor activity against mesothelioma and lung adenocarcinoma. Crizotinib is an ATP-competitive tyrosine kinase inhibitor that targets , and . Alectinib is known as an inhibitor but also targets , , , and . Sorafenib is a tyrosine kinase inhibitor that targets RAF kinase, , , , , and . Nintedanib is a multiple tyrosine kinase inhibitor that targets , and . In this review, we summarize the mechanisms of action of multitarget therapies and report the results of the latest clinical trials.
近年来，针对阿尔茨海默病等神经退行性疾病的多靶点药物已经得到了开发和深入研究。许多研究表明，多靶点药物对于肺癌和呼吸系统疾病也具有一定的治疗效果。培美曲塞是一种多靶点抗叶酸药物，对间皮瘤和肺腺癌具有很强的抗肿瘤活性。克唑替尼是一种 ATP 竞争性酪氨酸激酶抑制剂，靶向 、 、 。阿来替尼被认为是一种 抑制剂，但也靶向 、 、 、 和 。索拉非尼是一种靶向 RAF 激酶、 、 、 、 和 的酪氨酸激酶抑制剂。尼达尼布是一种多靶点酪氨酸激酶抑制剂，靶向 和 。在这篇综述中，我们总结了多靶点治疗的作用机制，并报告了最新的临床试验结果。
