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钯催化乙烯基碳酸乙烯酯与巴比妥衍生烯烃的[5 + 2]环加成反应。

Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes.

机构信息

Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, P.R. China.

College of Public Health, Zhengzhou University, Zhengzhou 450001, P.R. China.

出版信息

Org Lett. 2020 Sep 18;22(18):7158-7163. doi: 10.1021/acs.orglett.0c02508. Epub 2020 Sep 3.

DOI:10.1021/acs.orglett.0c02508
PMID:32883084
Abstract

A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.

摘要

钯/XantPhos 催化的 VEC 与具有孤立碳-碳双键的缺电子烯烃的 [5 + 2] 环加成反应，已被开发用于合成螺[巴比妥酸-四氢氧杂环庚烷]。该研究提供了一种方便的生物活性螺[巴比妥酸-四氢氧杂环庚烷]的合成方法。该反应产物还具有易于扩大规模和多功能转化的特点。

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