Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, PR China.
Org Biomol Chem. 2020 May 21;18(19):3638-3648. doi: 10.1039/d0ob00458h. Epub 2020 Apr 24.
Heterocycles are the fundamental structural motifs found in natural products and biologically active compounds. The construction of these structures is therefore an important task in organic chemistry. Vinylethylene carbonates (VECs) are versatile building blocks that can undergo transition metal catalysed decarboxylation to enable various kinds of interesting transformations. This review provides an overview of the significant achievements of VECs in palladium-catalysed annulations over the past five years. The flexible reactivity of VECs is demonstrated by various [3 + 2], [5 + n] and other types of annulations, which could offer powerful protocols for accessing diverse functionalised heterocycles.
杂环是天然产物和生物活性化合物中基本的结构单元。因此，构建这些结构是有机化学中的一项重要任务。乙烯基碳酸乙烯酯 (VEC) 是一种多功能的构建模块，可通过过渡金属催化脱羧反应进行转化，从而实现各种有趣的转化。本综述概述了过去五年中 VEC 在钯催化环化反应中的重要进展。VEC 的反应活性通过各种 [3 + 2]、[5 + n] 和其他类型的环化反应得到证明，为获得各种功能化杂环提供了有力的方法。
