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4
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In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae.泰万菌素对西班牙猪肺炎支原体田间分离株的体外活性
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欧洲南部采集样本中分离的猪支原体的抗菌敏感性分析。

Antimicrobial susceptibility profiles of porcine mycoplasmas isolated from samples collected in southern Europe.

机构信息

Unidad de Epidemiología y Medicina Preventiva, Instituto Universitario de Sanidad Animal y Seguridad Alimentaria, Universidad de Las Palmas de Gran Canaria, C/Trasmontana s/n, 35413, Arucas, Gran Canaria, Spain.

出版信息

BMC Vet Res. 2020 Sep 3;16(1):324. doi: 10.1186/s12917-020-02512-2.

DOI:10.1186/s12917-020-02512-2
PMID:32883288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469352/
Abstract

BACKGROUND

Mycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are significant pathogens for the porcine industry worldwide. The aim of the present study was to determine the antimicrobial susceptibility of six key antimicrobials (tylosin, tilmicosin, tylvalosin, lincomycin, tiamulin and valnemulin) routinely used for treating infections caused by these pathogens. Twenty-seven M. hyopneumoniae, 48 M. hyorhinis and 40 M. hyosynoviae field strains isolated from clinical samples from different Southern European countries between 2013 and 2018 using broth microdilution method were evaluated.

RESULTS

Tylvalosin exhibited the highest in vitro activity among the macrolides assayed, with MIC values 4 to 5 two-fold dilutions lower than those of tylosin and tilmicosin. The pleuromutilin valnemulin showed one of the highest in vitro activities against the three mycoplasma species. On the contrary, lincomycin exhibited the highest MIC values of the antimicrobials tested.

CONCLUSIONS

The data obtained in the present study supports the use of pleuromutilins and macrolides for the control of infections caused by porcine mycoplasmas. The use of lincomycin for the treatment of porcine mycoplasma infections should be carefully evaluated due to the presence of circulating field isolates with decreased susceptibility to this antimicrobial.

摘要

背景

猪肺炎支原体（M. hyopneumoniae）、猪鼻支原体（M. hyorhinis）和猪滑液支原体（M. hyosynoviae）是全球范围内对养猪业具有重要影响的病原体。本研究旨在测定六种常用于治疗这些病原体引起的感染的关键抗菌药物（泰乐菌素、替米考星、替米考星、泰万菌素、沃尼妙林和沃尼妙林）的药敏性。2013 年至 2018 年间，从不同南欧国家的临床样本中分离出 27 株 M. hyopneumoniae、48 株 M. hyorhinis 和 40 株 M. hyosynoviae ，采用肉汤微量稀释法进行了评估。

结果

在检测的大环内酯类药物中，泰万菌素表现出最高的体外活性，其 MIC 值比泰乐菌素和替米考星低 4 至 5 倍稀释度。截短侧耳素类沃尼妙林对三种支原体的体外活性最高。相反，林可霉素表现出测试的抗菌药物中最高的 MIC 值。

结论

本研究获得的数据支持使用截短侧耳素类和大环内酯类药物来控制猪支原体引起的感染。由于存在对这种抗菌药物敏感性降低的循环田间分离株，因此应谨慎评估林可霉素用于治疗猪支原体感染。