Syngenta, Jealott's Hill Research Centre, Bracknell, Berkshire RG42 6EY, UK.
Prog Nucl Magn Reson Spectrosc. 2020 Jun-Aug;118-119:1-9. doi: 10.1016/j.pnmrs.2020.02.002. Epub 2020 Mar 12.
A review of developments in fluorine NMR of relevance to synthesis, characterisation and industrial applications of small organic molecules. Developments considered include those in spectrometer technology, computational methods and pulse sequences. The review of 80 references outlines applications in areas of identification, quantitation, mixture analysis, reaction monitoring, environmental studies and fragment-based drug design.
综述了与小分子的合成、表征和工业应用相关的氟 NMR 的发展。所考虑的发展包括光谱仪技术、计算方法和脉冲序列的发展。对 80 篇参考文献的综述概述了在鉴定、定量、混合物分析、反应监测、环境研究和基于片段的药物设计等领域的应用。
