Kitajima Kazuhiro, Futani Hiroyuki, Tsuchitani Tatsuya, Takahashi Yoshiyuki, Yamakado Koichiro
Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan.
Department of Orthopedic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Case Rep Oncol. 2020 Jul 14;13(2):829-834. doi: 10.1159/000507663. eCollection 2020 May-Aug.
We here report on 2 cases of monostotic Paget's disease of bone, one in the ilium and the other in the skull, including quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate the response to bisphosphonate treatment. The quantitative parameters determined with those findings were decreased, with the maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake in case 1 and case 2 reduced by 48.8 and 60.3%, 46.6 and 58.8%, 24.3 and 60.5%, 87.0 and 11.8%, and 90.2 and 55.8%, respectively, while TRACP-5B and alkaline phosphatase (ALP) were also reduced by 39.5 and 88.6% and by 53.7 and 78.1%, respectively. Quantitative SPECT/CT parameter decreases were correlated with TRACP-5B and ALP, indicating the usefulness of this modality to examine treatment response.
我们在此报告2例单骨型骨佩吉特病，1例位于髂骨，另1例位于颅骨，包括通过骨单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）获得的定量值，这些值有助于评估对双膦酸盐治疗的反应。根据这些结果确定的定量参数有所下降，病例1和病例2的最大标准化摄取值（SUV）、SUV峰值、平均SUV、代谢骨体积和总骨摄取量分别降低了48.8%和60.3%、46.6%和58.8%、24.3%和60.5%、87.0%和11.8%、90.2%和55.8%，而抗酒石酸酸性磷酸酶5B（TRACP-5B）和碱性磷酸酶（ALP）也分别降低了39.5%和88.6%、53.7%和78.1%。SPECT/CT定量参数的下降与TRACP-5B和ALP相关，表明这种方法在检查治疗反应方面的有用性。
