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一名镰状细胞病患者接受羟基脲治疗后发生纯红细胞白血病

Pure Erythroid Leukemia in a Sickle Cell Patient Treated with Hydroxyurea.

作者信息

Yadav Dhiraj Kumar, Paul Thushara, Alhamar Mohamed, Inamdar Kedar, Guo Yue

机构信息

Department of Hematology and Oncology, Henry Ford Health System, Detroit, Michigan, USA.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan, USA.

出版信息

Case Rep Oncol. 2020 Jul 16;13(2):857-862. doi: 10.1159/000508361. eCollection 2020 May-Aug.

DOI:10.1159/000508361
PMID:32884531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7443646/
Abstract

We present a very rare case of pure erythroid leukemia arising in a young patient with sickle cell disease being treated with hydroxyurea for almost 5 years. Diagnosing and managing this rare condition has been a challenge and the majority of patients with pure erythroid leukemia have a very poor prognosis with survival in months despite treatment. This form of leukemia could be therapy related and in our case, hydroxyurea may have been responsible for the development of this aggressive condition.

摘要

我们报告了一例非常罕见的纯红细胞白血病病例，该病例发生在一名患有镰状细胞病的年轻患者身上，该患者接受羟基脲治疗近5年。诊断和处理这种罕见疾病具有挑战性，大多数纯红细胞白血病患者预后很差，尽管接受治疗，生存期也只有数月。这种白血病形式可能与治疗相关，在我们的病例中，羟基脲可能是导致这种侵袭性疾病发生的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/64d32c317715/cro-0013-0857-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/80ef7156f9de/cro-0013-0857-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/7d827827005b/cro-0013-0857-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/0c8df63fc48b/cro-0013-0857-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/64d32c317715/cro-0013-0857-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/80ef7156f9de/cro-0013-0857-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/7d827827005b/cro-0013-0857-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/0c8df63fc48b/cro-0013-0857-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d0/7443646/64d32c317715/cro-0013-0857-g04.jpg

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本文引用的文献

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Rare Tumors. 2018 May 14;10:2036361318773847. doi: 10.1177/2036361318773847. eCollection 2018.
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De novo pure erythroid leukemia: refining the clinicopathologic and cytogenetic characteristics of a rare entity.新发生的纯红细胞白血病：罕见实体的临床病理和细胞遗传学特征的精细化。
Mod Pathol. 2018 May;31(5):705-717. doi: 10.1038/modpathol.2017.175. Epub 2018 Jan 12.
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More than 1 abnormality is a dominant characteristic of pure erythroid leukemia.
超过一种异常是纯红细胞白血病的主要特征。
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Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia.患有克隆性细胞遗传学异常的骨髓增生异常综合征，在因镰状细胞贫血接受羟基脲治疗14年后继发致命性红系白血病。
Am J Hematol. 2015 Jul;90(7):E131-2. doi: 10.1002/ajh.24010.
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Histopathology. 2013 May;62(6):931-40. doi: 10.1111/his.12101.
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Am J Hematol. 2013 Mar;88(3):240-1. doi: 10.1002/ajh.23224. Epub 2012 May 6.
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Development of myelodysplastic syndrome and acute myeloid leukemia 15 years after hydroxyurea use in a patient with sickle cell anemia.羟基脲治疗 15 年后发生骨髓增生异常综合征和急性髓系白血病：镰状细胞贫血患者病例报告
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