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恶性外耳道炎继发颈内静脉血栓形成及舌下神经麻痹:一例报告并文献复习

Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy: a report and review of literature.

作者信息

Devaraja K, Nayak Dipak Ranjan

机构信息

Department of Otorhinolaryngology and Head and Neck Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Udupi, Karnataka, 576104, India.

出版信息

J Otol. 2020 Sep;15(3):112-116. doi: 10.1016/j.joto.2020.01.004. Epub 2020 Jan 25.

DOI:10.1016/j.joto.2020.01.004
PMID:32884563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7451676/
Abstract

Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa, which typically spreads to skull base to involve cranial nerves VII. Rarely can it also effect one or more of cranial nerves IX, X, XI, and XII. We present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial nerve. The patient though later on had internal jugular vein thrombosis, which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis, and later on, to aggravate the therapy. With proper blood sugar control and appropriate long term antibiotics, not only that the patient is disease free at one year follow up, but the cranial nerve deficits also recovered. Apart from sharing the clinical and management details of this patient, we have reviewed the relevant literature in the discussion, which has shed some light onto some of the interesting facts about this condition and its prognosis.

摘要

颞骨部分或全部以及周围软组织的炎症被称为恶性外耳道炎,其通常会蔓延至颅底,累及面神经 VII。极少数情况下,它也会影响舌咽神经(IX)、迷走神经(X)、副神经(XI)和舌下神经(XII)中的一条或多条。我们报告一例恶性外耳道炎病例,该病例表现为舌咽神经和舌下神经的症状性麻痹,而面神经 VII 未受累。尽管该患者后来出现了颈内静脉血栓形成,我们推测这是由于咽旁间隙受累所致,这促使我们重新考虑诊断,并随后加强了治疗。通过适当的血糖控制和合适的长期抗生素治疗,不仅患者在一年的随访中无疾病复发,而且颅神经功能缺损也得到了恢复。除了分享该患者的临床和治疗细节外,我们在讨论中还回顾了相关文献,这些文献揭示了有关这种疾病及其预后的一些有趣事实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338f/7451676/793613a25526/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338f/7451676/4bdb8eb801e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338f/7451676/793613a25526/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338f/7451676/4bdb8eb801e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/338f/7451676/793613a25526/gr2.jpg

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本文引用的文献

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Clinical characteristics and complications of skull base osteomyelitis: A 12-year study in a teaching hospital in South India.颅底骨髓炎的临床特征与并发症:印度南部一家教学医院的12年研究
J Family Med Prim Care. 2019 Mar;8(3):834-839. doi: 10.4103/jfmpc.jfmpc_62_19.
2
Skull base osteomyelitis: factors implicating clinical outcome.颅底骨髓炎:影响临床结局的因素。
Acta Neurol Belg. 2019 Sep;119(3):431-437. doi: 10.1007/s13760-019-01110-w. Epub 2019 Mar 6.
3
A Comprehensive Review of Skull Base Osteomyelitis: Diagnostic and Therapeutic Challenges among Various Presentations.
颅底骨髓炎综合综述:不同临床表现下的诊断与治疗挑战
Asian J Neurosurg. 2018 Oct-Dec;13(4):959-970. doi: 10.4103/ajns.AJNS_90_17.
4
Malignant Otitis Externa Outcomes: A Study of the University HealthSystem Consortium Database.恶性外耳道炎的治疗结果:一项基于大学卫生系统联盟数据库的研究
Ann Otol Rhinol Laryngol. 2018 Aug;127(8):514-520. doi: 10.1177/0003489418778056. Epub 2018 Jul 2.
5
Skull Base Osteomyelitis from Otitis Media Presenting as the Collet-Sicard Syndrome.中耳炎导致的颅底骨髓炎表现为科莱-西卡尔综合征。
Case Rep Otolaryngol. 2018 Mar 18;2018:1407417. doi: 10.1155/2018/1407417. eCollection 2018.
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Clinical Challenges in the Diagnosis and Treatment of Temporal Bone Osteomyelitis.颞骨骨髓炎诊断与治疗中的临床挑战
Case Rep Otolaryngol. 2017;2017:4097973. doi: 10.1155/2017/4097973. Epub 2017 Apr 9.
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