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度普利尤单抗治疗特应性皮炎和全秃的有效性。

Effectiveness of Dupilumab in the treatment of both atopic dermatitis and alopecia universalis.

作者信息

Call John E, Sahni Sakshi, Zug Kathryn A

机构信息

Department of Dermatology Dartmouth Hitchcock Medical Center Lebanon NH USA.

Department of Medicine University of Illinois at Chicago Chicago IL USA.

出版信息

Clin Case Rep. 2020 May 25;8(8):1337-1339. doi: 10.1002/ccr3.2915. eCollection 2020 Aug.

DOI:10.1002/ccr3.2915
PMID:32884748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7455431/
Abstract

Recent studies have demonstrated significant molecular parallels between atopic dermatitis and alopecia areata as predominantly TH2-mediated diseases. This case report highlights the potential for Dupilumab as a targeted biologic therapy in both atopic dermatitis and alopecia areata.

摘要

最近的研究表明，特应性皮炎和斑秃作为主要由TH2介导的疾病，在分子水平上有显著的相似之处。本病例报告强调了度普利尤单抗作为特应性皮炎和斑秃的靶向生物疗法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c259/7455431/6400b1fa43f6/CCR3-8-1337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c259/7455431/d387b5ff46c7/CCR3-8-1337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c259/7455431/6400b1fa43f6/CCR3-8-1337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c259/7455431/d387b5ff46c7/CCR3-8-1337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c259/7455431/6400b1fa43f6/CCR3-8-1337-g002.jpg

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本文引用的文献

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Dupilumab treatment for atopic dermatitis leading to unexpected treatment for alopecia universalis.度普利尤单抗治疗特应性皮炎导致泛发性斑秃的意外治疗情况。
JAAD Case Rep. 2019 Jan 11;5(2):111-112. doi: 10.1016/j.jdcr.2018.11.006. eCollection 2019 Feb.
2
Simultaneous improvement of alopecia universalis and atopic dermatitis in a patient treated with a JAK inhibitor.一名接受JAK抑制剂治疗的患者的普秃和特应性皮炎同时得到改善。
JAAD Case Rep. 2018 Jun 2;4(6):515-517. doi: 10.1016/j.jdcr.2017.12.016. eCollection 2018 Jul.
3
Dual efficacy of dupilumab in a patient with concomitant atopic dermatitis and alopecia areata.
Biomolecules. 2023 Mar 31;13(4):634. doi: 10.3390/biom13040634.
4
Short communication: Comments on hair disorders associated with dupilumab based on VigiBase.短篇通讯：基于 VigiBase 的有关度普利尤单抗相关毛发疾病的评论。
PLoS One. 2022 Jul 27;17(7):e0270906. doi: 10.1371/journal.pone.0270906. eCollection 2022.
5
Improvement of atopic dermatitis and alopecia universalis with dupilumab.度普利尤单抗治疗特应性皮炎和泛发性斑秃的疗效观察
Dermatol Reports. 2021 Dec 28;14(2):9359. doi: 10.4081/dr.2022.9359. eCollection 2022 Jun 16.
度普利尤单抗对一名同时患有特应性皮炎和斑秃患者的双重疗效。
Br J Dermatol. 2018 Aug;179(2):534-536. doi: 10.1111/bjd.16711. Epub 2018 Jun 15.
4
Alopecia areata after dupilumab for atopic dermatitis.度普利尤单抗治疗特应性皮炎后出现斑秃。
JAAD Case Rep. 2018 Jan 16;4(2):143-144. doi: 10.1016/j.jdcr.2017.11.020. eCollection 2018 Mar.
5
Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases.斑秃的细胞因子靶向治疗：来自特应性皮炎和其他炎症性皮肤病的经验教训。
J Investig Dermatol Symp Proc. 2018 Jan;19(1):S62-S64. doi: 10.1016/j.jisp.2017.10.005.
6
Therapeutic pipeline for atopic dermatitis: End of the drought?特应性皮炎的治疗领域：干旱的尽头？
J Allergy Clin Immunol. 2017 Sep;140(3):633-643. doi: 10.1016/j.jaci.2017.07.006.
7
The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.斑秃的变化格局：治疗范式
Adv Ther. 2017 Jul;34(7):1594-1609. doi: 10.1007/s12325-017-0542-7. Epub 2017 Jun 23.
8
JAK inhibitors in dermatology: The promise of a new drug class.皮肤科领域的JAK抑制剂：一类新药的前景
J Am Acad Dermatol. 2017 Apr;76(4):736-744. doi: 10.1016/j.jaad.2016.12.005. Epub 2017 Jan 28.
9
Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.斑秃疾病活动度及对皮质类固醇治疗反应的生物标志物。
Exp Dermatol. 2016 Apr;25(4):282-6. doi: 10.1111/exd.12918. Epub 2016 Mar 3.
10
History of atopy or autoimmunity increases risk of alopecia areata.特应性或自身免疫病史会增加斑秃的风险。
J Am Acad Dermatol. 2009 Oct;61(4):581-91. doi: 10.1016/j.jaad.2009.04.031. Epub 2009 Jul 16.