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度普利尤单抗治疗特应性皮炎和泛发性斑秃的疗效观察

Improvement of atopic dermatitis and alopecia universalis with dupilumab.

作者信息

Alotaibi Lama, Alfawzan Abdulrahman, Alharthi Raghad, Al Sheikh Afaf

机构信息

Division of Dermatology, Department of Medicine, Prince Sultan Military Medical City, Riyadh.

College of Medicine, King Saud University for Health Sciences, Riyadh.

出版信息

Dermatol Reports. 2021 Dec 28;14(2):9359. doi: 10.4081/dr.2022.9359. eCollection 2022 Jun 16.

DOI:10.4081/dr.2022.9359
PMID:35795833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9251532/
Abstract

Dupilumab is an interleukin-4 receptor alpha antagonist that showed significant improvement of atopic dermatitis (AD). Many reports have shown significant resolution of alopecia areata, alopecia universalis and alopecia totalis after dupilumab treatment for AD. We present one of reported cases that showed improvement of underlying alopecia universalis treated with dupilumab.

摘要

度普利尤单抗是一种白细胞介素-4受体α拮抗剂，已显示出对特应性皮炎（AD）有显著改善作用。许多报告表明，在使用度普利尤单抗治疗AD后，斑秃、全秃和普秃有显著缓解。我们报告其中一例使用度普利尤单抗治疗后潜在普秃得到改善的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/d362ce07690c/dr-14-2-9359-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/70f98997bb90/dr-14-2-9359-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/936bbf8144de/dr-14-2-9359-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/3ed993a02c8a/dr-14-2-9359-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/d362ce07690c/dr-14-2-9359-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/70f98997bb90/dr-14-2-9359-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/936bbf8144de/dr-14-2-9359-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/3ed993a02c8a/dr-14-2-9359-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9650/9251532/d362ce07690c/dr-14-2-9359-g004.jpg

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本文引用的文献

1
Full scalp hair regrowth in a 4-year-old girl with alopecia areata and atopic dermatitis treated with dupilumab.用度普利尤单抗治疗的一名患有斑秃和特应性皮炎的4岁女孩头皮毛发完全再生。
JAAD Case Rep. 2020 Oct 15;6(12):1286-1287. doi: 10.1016/j.jdcr.2020.10.010. eCollection 2020 Dec.
2
Effectiveness of Dupilumab in the treatment of both atopic dermatitis and alopecia universalis.度普利尤单抗治疗特应性皮炎和全秃的有效性。
Clin Case Rep. 2020 May 25;8(8):1337-1339. doi: 10.1002/ccr3.2915. eCollection 2020 Aug.
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Alopecia areata development in atopic dermatitis patients treated with dupilumab.
度普利尤单抗治疗炎症性皮肤病：系统评价。
Biomolecules. 2023 Mar 31;13(4):634. doi: 10.3390/biom13040634.
使用度普利尤单抗治疗的特应性皮炎患者中斑秃的发生情况。
J Eur Acad Dermatol Venereol. 2020 Oct;34(10):e612-e613. doi: 10.1111/jdv.16493. Epub 2020 May 19.
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Dupilumab for treatment of atopic dermatitis.度普利尤单抗治疗特应性皮炎。
Expert Rev Clin Pharmacol. 2018 May;11(5):467-474. doi: 10.1080/17512433.2018.1449642. Epub 2018 Mar 20.
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Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing.斑秃特征分析显示 TH1、TH2 和 IL-23 细胞因子激活，而无平行的 TH17/TH22 偏倚。
J Allergy Clin Immunol. 2015 Nov;136(5):1277-87. doi: 10.1016/j.jaci.2015.06.032. Epub 2015 Aug 24.
6
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.斑秃的全基因组荟萃分析确定了 HLA 关联并揭示了两个新的易感基因座。
Nat Commun. 2015 Jan 22;6:5966. doi: 10.1038/ncomms6966.
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Cytokine modulation of atopic dermatitis filaggrin skin expression.细胞因子对特应性皮炎中丝聚合蛋白皮肤表达的调节作用。
J Allergy Clin Immunol. 2009 Sep;124(3 Suppl 2):R7-R12. doi: 10.1016/j.jaci.2009.07.012.
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Viral infections in atopic dermatitis: pathogenic aspects and clinical management.特应性皮炎中的病毒感染：发病机制及临床管理
J Allergy Clin Immunol. 2003 Oct;112(4):667-74. doi: 10.1016/j.jaci.2003.07.001.
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Flow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease.对特应性皮炎患者外周血单个核细胞中白细胞介素-4、白细胞介素-13和干扰素-γ表达进行流式细胞术分析以及检测循环白细胞介素-13，为2型细胞因子参与该疾病提供了证据。
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