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贝伐单抗作为一名14岁女孩因巨大视神经乳头小疣所致脉络膜新生血管的一种治疗选择。

Bevacizumab as a treatment option for choroidal neovascularisation due to large optic nerve drusen in a 14-year-old girl.

作者信息

Steinhorst Nils Alexander, Spitzer Martin, Skevas Christos

机构信息

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

GMS Ophthalmol Cases. 2020 Aug 6;10:Doc33. doi: 10.3205/oc000160. eCollection 2020.

DOI:10.3205/oc000160
PMID:32884887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7452948/
Abstract

To report the effects of a single intravitreous injection of bevacizumab for the treatment of secondary choroideal neovascularisation due to large optic disc drusen. A 14-year-old female patient with painless loss of vision in one eye presented with unusually large optic disc drusen and juxtapapillary choroidal neovascularisation with subretinal hemorrhage. She was treated with a single intravitreous injection of bevacizumab. Visual acuity increased from 20/100 to 20/25 within 4 weeks after injection and remained at this level during the 12-month follow-up period. Bevacizumab is a possible primary treatment option for secondary choroidal neovascularisation due to large optic disc drusen in children as an alternative to other more invasive or complex procedures.

摘要

报告单次玻璃体内注射贝伐单抗治疗因巨大视盘玻璃膜疣所致继发性脉络膜新生血管的疗效。一名14岁女性患者,单眼无痛性视力丧失,伴有异常巨大的视盘玻璃膜疣和视乳头旁脉络膜新生血管及视网膜下出血。她接受了单次玻璃体内注射贝伐单抗治疗。注射后4周内视力从20/100提高到20/25,并在12个月的随访期内维持在该水平。对于儿童因巨大视盘玻璃膜疣所致继发性脉络膜新生血管,贝伐单抗是一种可能的主要治疗选择,可替代其他更具侵入性或复杂的手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/7452948/3ff27cbd9f31/OC-10-33-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/7452948/2f0ad2077295/OC-10-33-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/7452948/3ff27cbd9f31/OC-10-33-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/7452948/2f0ad2077295/OC-10-33-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee8d/7452948/3ff27cbd9f31/OC-10-33-g-002.jpg

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本文引用的文献

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Choroidal neovascularisation associated with optic nerve head drusen: Case report and review of literature.与视盘玻璃疣相关的脉络膜新生血管形成:病例报告及文献综述
Arch Soc Esp Oftalmol (Engl Ed). 2019 Mar;94(3):149-152. doi: 10.1016/j.oftal.2018.07.008. Epub 2018 Oct 2.
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Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti-vascular endothelial growth factor therapy of macular diseases.抗血管内皮生长因子治疗方案的基本原则:黄斑疾病玻璃体内抗血管内皮生长因子治疗的优化应用
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