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支持出院服务与住院治疗评估(SITE)试验:一项比较强化社区护理服务与常规住院治疗对青少年严重精神障碍患者(自我伤害、功能障碍、教育和临床结局)有效性的随机对照试验

Supported discharge service versus inpatient care evaluation (SITE): a randomised controlled trial comparing effectiveness of an intensive community care service versus inpatient treatment as usual for adolescents with severe psychiatric disorders: self-harm, functional impairment, and educational and clinical outcomes.

机构信息

King's College London, London, UK.

出版信息

Eur Child Adolesc Psychiatry. 2021 Sep;30(9):1427-1436. doi: 10.1007/s00787-020-01617-1. Epub 2020 Sep 3.

Abstract

Clinical guidelines recommend intensive community care service treatment (ICCS) to reduce adolescent psychiatric inpatient care. We have previously reported that the addition of ICCS led to a substantial decrease in hospital use and improved school re-integration. The aim of this study is to undertake a randomised controlled trial (RCT) comparing an inpatient admission followed by an early discharge supported by ICCS with usual inpatient admission (treatment as usual; TAU). In this paper, we report the impact of ICCS on self-harm and other clinical and educational outcomes. 106 patients aged 12-18 admitted for psychiatric inpatient care were randomised (1:1) to either ICCS or TAU. Six months after randomisation, we compared the two treatment arms on the number and severity of self-harm episodes, the functional impairment, severity of psychiatric symptoms, clinical improvement, reading and mathematical ability, weight, height and the use of psychological therapy and medication. At six-month follow-up, there were no differences between the two groups on most measures. Patients receiving ICCS were significantly less likely to report multiple episodes (five or more) of self-harm (OR = 0.18, 95% CI: 0.05-0.64). Patients admitted to private inpatient units spent on average 118.4 (95% CI: 28.2-208.6) fewer days in hospitals if they were in the ICCS group compared to TAU. The addition of ICCS to TAU may lower the risk of multiple self-harm and may reduce the duration of inpatient stay, especially in those patients admitted for private care. Early discharge with ICCS appears to be a viable alternative to standard inpatient treatment.

摘要

临床指南建议采用强化社区护理服务治疗(ICCS)来减少青少年精神科住院治疗。我们之前曾报道过,加入 ICCS 可显著减少住院治疗次数并提高重返学校的比例。本研究旨在开展一项随机对照试验(RCT),比较 ICCS 支持下的早期出院与常规住院治疗(常规治疗;TAU)对青少年的影响。本文报道了 ICCS 对自伤和其他临床及教育结果的影响。106 名年龄在 12-18 岁之间因精神科住院而接受治疗的患者被随机(1:1)分配至 ICCS 或 TAU 组。在随机分组后的 6 个月时,我们比较了两组患者的自伤发作次数和严重程度、功能障碍、精神症状严重程度、临床改善、阅读和数学能力、体重、身高以及心理治疗和药物治疗的使用情况。在 6 个月随访时,两组患者在大多数指标上均无差异。接受 ICCS 的患者报告多次(五次或更多次)自伤的可能性明显降低(OR=0.18,95%CI:0.05-0.64)。与 TAU 相比,接受 ICCS 的患者如果入住私立住院病房,平均住院天数减少 118.4 天(95%CI:28.2-208.6)。与 TAU 相比,将 ICCS 加入 TAU 可能会降低多次自伤的风险,并可能缩短住院时间,特别是对那些因私立医疗而入院的患者。ICCS 支持下的早期出院似乎是标准住院治疗的可行替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/8440265/6ca035263ef4/787_2020_1617_Fig1_HTML.jpg

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