食用海藻与新诊断的非酒精性脂肪性肝病之间的关联：TCLSIH队列研究。

Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: The TCLSIH Cohort Study.

作者信息

Li Huiping, Gu Yeqing, Wu Xiaohui, Rayamajhi Sabina, Bian Shanshan, Zhang Qing, Meng Ge, Liu Li, Wu Hongmei, Zhang Shunming, Wang Yawen, Zhang Tingjing, Wang Xuena, Thapa Amrish, Sun Shaomei, Wang Xing, Jia Qiyu, Song Kun, Niu Kaijun

机构信息

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

出版信息

Liver Int. 2021 Feb;41(2):311-320. doi: 10.1111/liv.14655.

DOI:10.1111/liv.14655

PMID:32885579

Abstract

BACKGROUND & AIMS: Seaweeds are rich sources of anti-oxidants and anti-inflammatory properties, which are beneficial to non-alcoholic fatty liver disease (NAFLD). However, whether seaweed consumption is associated with NAFLD is unknown. We investigated the association of seaweed consumption with newly diagnosed NAFLD in a large-scale adult population.

METHODS

This cross-sectional study involved 24 572 participants aged over 18 years. NAFLD was diagnosed by results of liver ultrasonography and alcohol intake. Dietary information was assessed using a validated and standardized 100-item food frequency questionnaire. Multivariate logistic analysis was used to evaluate the association between seaweed consumption and NAFLD.

RESULTS

The prevalence of newly diagnosed NAFLD was 20.1%. After adjustment for sociodemographic characteristics, lifestyle factors, and other dietary intakes, the multivariable adjusted odds ratios (95% confidence intervals) of newly diagnosed NAFLD across seaweed consumption were 1.00 (reference) for almost never, 1.03 (0.93, 1.15) for <1 time/wk, 1.01 (0.90, 1.13) for 1 time/wk, and 0.84 (0.73, 0.96) for >1 times/wk (P for trend < .001). Stratified analyses suggested a potential effect modification by obesity status; the odds ratios (95% confidence intervals) across extreme quartiles was 0.77 (0.66, 0.91) in non-obese participants and 1.02 (0.79, 1.33) in obese participants (P for interaction < .001).

CONCLUSION

Seaweed consumption is negatively associated with NAFLD, especially in non-obese participants.

摘要

背景与目的

海藻富含抗氧化剂和抗炎特性，对非酒精性脂肪性肝病（NAFLD）有益。然而，食用海藻是否与NAFLD相关尚不清楚。我们在大规模成年人群中调查了食用海藻与新诊断的NAFLD之间的关联。

方法

这项横断面研究纳入了24572名18岁以上的参与者。通过肝脏超声检查结果和酒精摄入量诊断NAFLD。使用经过验证和标准化的100项食物频率问卷评估饮食信息。采用多因素逻辑分析评估食用海藻与NAFLD之间的关联。

结果

新诊断的NAFLD患病率为20.1%。在调整社会人口学特征、生活方式因素和其他饮食摄入后，食用海藻的新诊断NAFLD的多变量调整优势比（95%置信区间）几乎从不食用为1.00（参考值），每周<1次为1.03（0.93，1.15），每周1次为1.01（0.90，1.13），每周>1次为0.84（0.73，0.96）（趋势P<0.001）。分层分析表明肥胖状态可能存在效应修饰；非肥胖参与者中极端四分位数的优势比（95%置信区间）为0.77（0.66，0.91），肥胖参与者中为1.02（0.79，1.33）（交互作用P<0.001）。