Iwasa Masayo, Ozu Naoki, Yamakage Hajime, Kato Hisashi, Ishikawa Misato, Kanasaki Megumi, Masuda Izuru, Tanaka Masashi, Satoh-Asahara Noriko
Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan.
Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara 634-8522, Japan.
Nutrients. 2025 Aug 6;17(15):2566. doi: 10.3390/nu17152566.
: We aimed to identify questionnaire items associated with an increased risk of developing hepatic steatosis in the general population. : A total of 15,063 individuals aged ≥20 years who underwent general health checkups and had no hepatic steatosis at baseline were included. The relationship between questionnaire data at baseline and hepatic steatosis incidence over a median 4.2-year follow-up was investigated across body mass index (BMI) categories. : Among 15,063 individuals (mean [SD] age, 47.1 [10.2] years; 6769 [44.9%] male; mean [SD] BMI, 21.4 [2.6] kg/m), 1889 individuals (12.5%) developed hepatic steatosis during follow-up. After adjusting for age, sex, and factors related to metabolic diseases and liver injury, the strongest questionnaire-based risk factor for hepatic steatosis was self-reported weight gain of 10 kg or more after the age of 20 across all BMI categories: total population (hazard ratio [HR], 2.11; 95% confidence interval [CI], 1.90-2.34; < 0.001), Category 1 (BMI < 22) (HR, 2.33; 95% CI, 1.86-2.91; < 0.001), Category 2 (BMI 22 to <25) (HR, 1.43; 95% CI, 1.25-1.63; < 0.001), and Category 3 (BMI ≥ 25) (HR, 1.41; 95% CI, 1.12-1.77; = 0.003). : In this cohort study, self-reported weight gain of 10 kg or more after the age of 20 was associated with an increased risk of hepatic steatosis, independent of baseline BMI. Questionnaires capturing weight gain history may support universal screening efforts to identify individuals at elevated risk.
我们旨在确定与普通人群发生肝脂肪变性风险增加相关的问卷项目。纳入了总共15063名年龄≥20岁且在基线时无肝脂肪变性的接受一般健康检查的个体。在不同体重指数（BMI）类别中，研究了基线时的问卷数据与中位4.2年随访期间肝脂肪变性发生率之间的关系。在15063名个体（平均[标准差]年龄，47.1[10.2]岁；6769名[44.9%]男性；平均[标准差]BMI，21.4[2.6]kg/m²）中，1889名个体（12.5%）在随访期间发生了肝脂肪变性。在调整年龄、性别以及与代谢疾病和肝损伤相关的因素后，在所有BMI类别中，基于问卷的肝脂肪变性最强风险因素是自我报告的20岁后体重增加10千克或更多：总体人群（风险比[HR]，2.11；95%置信区间[CI]，1.90 - 2.34；P < 0.001），第1类（BMI < 22）（HR，2.33；95%CI，1.86 - 2.91；P < 0.001），第2类（BMI 22至<25）（HR，1.43；95%CI，1.25 - 1.63；P < 0.001），以及第3类（BMI≥25）（HR，1.41；95%CI，1.12 - 1.77；P = 0.003）。在这项队列研究中，自我报告的20岁后体重增加10千克或更多与肝脂肪变性风险增加相关，独立于基线BMI。记录体重增加历史的问卷可能有助于识别高风险个体的普遍筛查工作。
