Department of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee.
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Am J Transplant. 2021 Mar;21(3):938-949. doi: 10.1111/ajt.16295. Epub 2020 Sep 23.
Solid organ transplant (SOT) recipients are at increased risk of influenza disease and associated complications. The mainstay of prevention is the annual standard-dose influenza vaccine, as studies showed decreased influenza-related morbidity and mortality in vaccinated SOT recipients compared to those unvaccinated. Nonetheless, the immune response in this high-risk population is suboptimal compared to healthy individuals. Over the past two decades, several vaccination strategies have been investigated to overcome this inadequate immune response in SOT recipients. Howbeit, the best vaccination strategy and optimal timing of influenza vaccination remain unclear. This review will provide a detailed summary of studies of various influenza vaccination strategies in adult SOT recipients, discussing immunogenicity results, and addressing their limitations and knowledge gaps.
实体器官移植（SOT）受者患流感疾病及相关并发症的风险增加。预防的主要手段是每年接种标准剂量的流感疫苗，研究表明，与未接种疫苗的 SOT 受者相比，接种疫苗的 SOT 受者的流感相关发病率和死亡率降低。然而，与健康个体相比，高危人群的免疫反应仍不理想。在过去的二十年中，已经研究了几种疫苗接种策略来克服 SOT 受者中这种免疫反应不足的问题。然而，最佳的疫苗接种策略和流感疫苗接种的最佳时间仍不清楚。本综述将详细总结成人 SOT 受者中各种流感疫苗接种策略的研究，讨论其免疫原性结果，并阐述其局限性和知识空白。
