Eating Disorder Unit, Mental Health Center Ballerup, Ballerup, Denmark.
Center for Eating Disorders, Odense University Hospital, Odense, Denmark.
Eur Eat Disord Rev. 2020 Nov;28(6):605-619. doi: 10.1002/erv.2787. Epub 2020 Sep 4.
Anorexia nervosa (AN) is a serious mental illness with high rates of relapse and mortality. Psychiatric comorbidities are common but their impact on the prognosis is largely unknown.
The aim was to investigate the influence of psychiatric comorbidity on weight gain during treatment of AN.
A systematic search was performed in PubMed/MEDLINE, EMBASE and PsycINFO. Studies evaluating psychiatric comorbidity as a predictor for treatment outcome (weight gain) were included, however, comorbid alcohol/drug addiction was excluded from this review.
Four thousand five hundred and twenty six publications were identified from which 15 were included. The majority of the included studies had a prospective open naturalistic study design, a short-term follow-up period, and were based on small populations of primarily adolescent and adult women. Four studies indicate depression, and two obsessiveness as negative prognostic factors, whilst one study indicated moderate depression and yet another, neuroticism, as positive predictors for weight gain.
The systematic scoping review found a large number of publications whereof only a few directly described the influence of psychiatric comorbidity on weight gain in AN. Overall, studies were heterogeneous in design, purpose and outcome making comparisons difficult. Findings were divergent but depression had a negative influence on weight gain in four studies.
神经性厌食症（AN）是一种严重的精神疾病，其复发率和死亡率都很高。精神共病很常见，但它们对预后的影响在很大程度上尚不清楚。
本研究旨在探讨精神共病对 AN 治疗期间体重增加的影响。
在 PubMed/MEDLINE、EMBASE 和 PsycINFO 中进行系统检索。纳入评估精神共病作为治疗结局（体重增加）预测因素的研究，但本综述排除了酒精/药物成瘾的共病。
从 4526 篇文献中确定了 15 篇符合条件的文献。纳入的大多数研究具有前瞻性开放性自然研究设计、短期随访期，并且基于主要为青少年和成年女性的小人群。四项研究表明抑郁和强迫症是负面预后因素，而一项研究表明中度抑郁，另一项研究则表明神经质是体重增加的阳性预测因素。
系统范围综述发现了大量出版物，其中只有少数直接描述了精神共病对 AN 体重增加的影响。总体而言，研究在设计、目的和结果方面存在很大的异质性，使得比较变得困难。研究结果存在分歧，但四项研究表明抑郁对体重增加有负面影响。
