体重和饮食态度影响饮食障碍儿童和青少年抑郁症状的改善：一项前瞻性多中心队列研究。

Body weight and eating attitudes influence improvement of depressive symptoms in children and pre-adolescents with eating disorders: a prospective multicenter cohort study.

机构信息

Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-Oka, Fukushima, Fukushima, 960-1295, Japan.

Department of Pediatrics, Fukuoka University Faculty of Medicine, Fukuoka, Japan.

出版信息

BMC Pediatr. 2024 Aug 27;24(1):551. doi: 10.1186/s12887-024-05024-2.

DOI:10.1186/s12887-024-05024-2

PMID:39192238

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11348658/

Abstract

BACKGROUND

Pediatric patients with eating disorders in a multicenter joint study on 11 facilities were enrolled and prospectively investigated to determine whether improvement in body weight, eating attitudes, and psychosocial factors in children with eating disorders would also improve depressive symptoms.

METHODS

In this study, 91 patients were enrolled between April 2014 and March 2016. The severity of underweight was assessed using the body mass index-standard deviation score (BMI-SDS), eating behavior was assessed using the children's eating attitude test (ChEAT26), the outcome of childhood eating disorders was assessed using the childhood eating disorder outcome scale, and depressive symptoms were assessed using the Children's Depression Inventory (CDI) score.

RESULTS

After 12 months of treatment, depressive symptoms were evaluated in 62 of the 91 cases where it was evaluated at the initial phase. There was no difference in background characteristics between the included patients and the 29 patients who dropped out. A paired-sample t-test revealed a significant decrease in CDI scores after 12 months of treatment (p < 0.001, 95% CI: 2.401-7.373) and a significant increase in the BMI-SDS (p < 0.001, 95% CI: - 2.41973-1.45321). Multiple regression analysis revealed that BMI-SDS and ChEAT26 scores at the initial phase were beneficial in CDI recovery. In addition, BMI-SDS at the initial phase was useful for predicting BMI-SDS recovery after 12 months of treatment.

CONCLUSIONS

Depressive symptoms in children with eating disorders improved with therapeutic intervention on body weight and eating attitudes.

TRIAL REGISTRATION

The Clinical Trial Number for this study is UMIN000055004.

摘要

背景

在一项针对 11 家医疗机构的多中心联合研究中，纳入了患有饮食障碍的儿科患者，并进行了前瞻性研究，以确定饮食障碍儿童的体重、饮食态度和心理社会因素的改善是否也会改善抑郁症状。

方法

本研究共纳入 91 例患者，纳入时间为 2014 年 4 月至 2016 年 3 月。采用体重指数标准差评分（BMI-SDS）评估消瘦严重程度，采用儿童饮食态度测试（ChEAT26）评估饮食行为，采用儿童饮食障碍结局量表评估儿童饮食障碍结局，采用儿童抑郁量表（CDI）评分评估抑郁症状。

结果

在初始阶段评估的 91 例患者中，有 62 例在治疗 12 个月后评估了抑郁症状。纳入患者与 29 例脱落患者的背景特征无差异。配对样本 t 检验显示，治疗 12 个月后 CDI 评分显著下降（p<0.001，95%CI：2.401-7.373），BMI-SDS 显著增加（p<0.001，95%CI：-2.41973-1.45321）。多元回归分析显示，初始阶段的 BMI-SDS 和 ChEAT26 评分对 CDI 恢复有益。此外，初始阶段的 BMI-SDS 有助于预测治疗 12 个月后 BMI-SDS 的恢复。