Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan.
Jpn J Ophthalmol. 2020 Nov;64(6):597-604. doi: 10.1007/s10384-020-00769-6. Epub 2020 Sep 5.
Several studies of Western patients with age-related macular degeneration (AMD) have investigated reading performance that improved at high levels of illumination; however, the relation between reading performance and macular function has not been evaluated in detail in Japan. The goals of this study were to evaluate the effect of different levels of illumination on reading performance in Japanese patients with AMD and determine the factors, such as macular function, that affect these results.
Cross-sectional study.
We prospectively included 39 patients with bilateral AMD or maculopathy. We evaluated reading performance; reading acuity (RA), critical print size (CPS), and maximal reading speed (MRS) using charts with Japanese sentences based on the MNREAD-J in 500-7500 lx. Patients were classified into two groups based on the presence of a central scotoma (CS) or no CS (NCS) diagnosed by microperimetry.
The RA improved significantly in 500-7500 lx in both groups (NCS, p = 0.001; CS, p = 0.046). The RA improvement differed significantly (2000 lx, p = 0.021; 5,000 lx; p = 0.021; 7500 lx, p = 0.047) between 500 lx and other illumination levels only in the NCS group and then plateaued over 2000 lx. The CPS and MRS did not improve significantly at any illumination level.
These results suggest that the difference in macular function was related to improvement in the RA with increased illumination in Japanese patients with AMD.
几项针对与年龄相关的黄斑变性（AMD）的西方患者的研究已经调查了在高照度下改善的阅读表现；然而，在日本，尚未详细评估阅读表现与黄斑功能之间的关系。本研究的目的是评估不同照度对日本 AMD 患者阅读表现的影响，并确定影响这些结果的因素，如黄斑功能。
横断面研究。
我们前瞻性纳入了 39 名双侧 AMD 或黄斑病变患者。我们使用基于 MNREAD-J 的日语句子图表在 500-7500 lx 下评估阅读表现；阅读视力（RA）、临界印刷尺寸（CPS）和最大阅读速度（MRS）。根据微视野诊断，患者分为存在中心暗点（CS）或无中心暗点（NCS）两组。
两组患者在 500-7500 lx 下 RA 均显著提高（NCS，p=0.001；CS，p=0.046）。RA 改善在仅 NCS 组在 500 lx 与其他照度水平之间差异显著（2000 lx，p=0.021；5000 lx，p=0.021；7500 lx，p=0.047），然后在 2000 lx 以上趋于平稳。在任何照度水平下，CPS 和 MRS 均无显著改善。
这些结果表明，在日本 AMD 患者中，黄斑功能的差异与增加照度时 RA 的改善有关。
