IFN-γ directly inhibits the activity of erythropoietin in human erythroid progenitors.
作者信息
Araki Daisuke, Alvarado Luigi J, Huntsman Heather D, Smith Richard H, Larochelle Andre
机构信息
National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
出版信息
Blood Cells Mol Dis. 2020 Nov;85:102488. doi: 10.1016/j.bcmd.2020.102488. Epub 2020 Aug 21.
Abstract
摘要
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IFN-γ directly inhibits the activity of erythropoietin in human erythroid progenitors.干扰素-γ直接抑制人红系祖细胞中促红细胞生成素的活性。
Blood Cells Mol Dis. 2020 Nov;85:102488. doi: 10.1016/j.bcmd.2020.102488. Epub 2020 Aug 21.
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TRPC3 activation by erythropoietin is modulated by TRPC6.红细胞生成素对瞬时受体电位通道3（TRPC3）的激活作用受瞬时受体电位通道6（TRPC6）的调控。
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Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.鉴定出一条对原代红系祖细胞增殖和分化至关重要的新途径。
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Specific binding of interferon-gamma to high affinity receptors on human erythroid colony-forming cells.干扰素-γ与人红系集落形成细胞上高亲和力受体的特异性结合。
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An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo).一种同时表达c-mpl和促红细胞生成素受体（Epo-R）的红系和巨核系共同前体细胞系（B1647），对巨核细胞生长和发育因子（MGDF）有反应，但对促红细胞生成素（Epo）无反应，它会增殖并改变珠蛋白链的合成。
Br J Haematol. 1997 Sep;98(3):549-59. doi: 10.1046/j.1365-2141.1997.2793096.x.
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Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.艾曲波帕在由 IFN-γ 介导的炎症条件下维持人造血干细胞和祖细胞。
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Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.铁元素对红细胞生成的调节与 Scribble 介导的促红细胞生成素受体的控制有关。
J Exp Med. 2018 Feb 5;215(2):661-679. doi: 10.1084/jem.20170396. Epub 2017 Dec 27.
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Erythropoietin resistance contributes to anaemia in chronic heart failure and relates to aberrant JAK-STAT signal transduction.促红细胞生成素抵抗导致慢性心力衰竭贫血，并与 JAK-STAT 信号转导异常有关。
Int J Cardiol. 2013 Apr 15;164(3):359-64. doi: 10.1016/j.ijcard.2011.07.045. Epub 2011 Aug 6.
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Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex.不对称的促红细胞生成素：促红细胞生成素受体复合物的对称信号传导
Mol Cell. 2009 Jan 30;33(2):266-74. doi: 10.1016/j.molcel.2008.11.026.
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Anemia of chronic disease.慢性病贫血
N Engl J Med. 2005 Mar 10;352(10):1011-23. doi: 10.1056/NEJMra041809.
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Efficiency of signalling through cytokine receptors depends critically on receptor orientation.细胞因子受体信号传导的效率关键取决于受体的取向。
Nature. 1998 Oct 1;395(6701):511-6. doi: 10.1038/26773.
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Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction.促红细胞生成素（EPO）使促红细胞生成素受体的细胞外结构域二聚化：一种高亲和力相互作用和一种低亲和力相互作用。
Biochemistry. 1996 Feb 6;35(5):1681-91. doi: 10.1021/bi9524272.
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