超重或肥胖儿童和青少年的生活质量：阻塞性睡眠呼吸暂停的影响。
Quality of life in children and adolescents with overweight or obesity: Impact of obstructive sleep apnea.
机构信息
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Lykkebækvej 1, 4600 Køge, Denmark.
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Lykkebækvej 1, 4600 Køge, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Holbæk University Hospital, Smedelundsgade 60, 4300 Holbæk, Denmark.
出版信息
Int J Pediatr Otorhinolaryngol. 2020 Nov;138:110320. doi: 10.1016/j.ijporl.2020.110320. Epub 2020 Aug 18.
OBJECTIVES
To investigate the association between obstructive sleep apnea (OSA) and health related quality of life (HRQOL) in children and adolescents referred to an obesity treatment clinic. In addition, we examined the association between body mass index standard deviation score (BMI SDS) and HRQOL comparing children and adolescents with overweight or obesity without OSA with a control group of children and adolescents with normal weight without OSA.
METHODS
This cross-sectional study included 130 children and adolescents with overweight or obesity (BMI SDS > 1.28) aged 7-18 years recruited from an obesity treatment clinic. The control group consisted of 28 children and adolescents with normal weight (BMI SDS ≤ 1.28) aged 7-18 years recruited from schools. Sleep examinations were performed using a type 3 portable sleep monitor, Nox T3. OSA was defined as apnea-hypopnea index (AHI) ≥ 2. HRQOL was measured by the Pediatric Quality of Life Inventory (PedsQL) 4.0 generic core scale.
RESULTS
A total of 56 children and adolescents with overweight or obesity were diagnosed with OSA (43%). The children and adolescents with OSA were older (p = 0.01) and had higher BMI SDS (p = 0.04) than children and adolescents without OSA. In generalized linear regression analyses adjusted for age, sex, BMI SDS and pubertal development stage there was no association between OSA or AHI and HRQOL in children and adolescents with overweight or obesity. In the analysis, including children and adolescents without OSA and the normal-weight control group, the generalized linear regression adjusted for age, sex and AHI revealed an association between BMI SDS and HRQOL (p < 0.001).
CONCLUSION
We found no association between AHI or OSA and HRQOL in children and adolescents with overweight or obesity. However, we found an association between BMI SDS and HRQOL in children and adolescents without OSA.
目的
研究肥胖治疗门诊就诊的儿童和青少年阻塞性睡眠呼吸暂停（OSA）与健康相关生活质量（HRQOL）之间的关系。此外，我们还比较了超重或肥胖且无 OSA 的儿童和青少年与正常体重且无 OSA 的对照组儿童和青少年之间，BMI 标准差评分（BMI SDS）与 HRQOL 的关系。
方法
本横断面研究纳入了 130 名年龄在 7-18 岁的超重或肥胖（BMI SDS>1.28）儿童和青少年，他们均来自肥胖治疗门诊。对照组由 28 名年龄在 7-18 岁的正常体重（BMI SDS≤1.28）儿童和青少年组成，他们来自学校。使用类型 3 便携式睡眠监测仪（Nox T3）进行睡眠检查。OSA 定义为呼吸暂停低通气指数（AHI）≥2。使用儿童生活质量问卷（PedsQL）4.0 通用核心量表评估 HRQOL。
结果
共 56 名超重或肥胖儿童和青少年被诊断为 OSA（43%）。与无 OSA 的儿童和青少年相比，患有 OSA 的儿童和青少年年龄更大（p=0.01），BMI SDS 更高（p=0.04）。在调整年龄、性别、BMI SDS 和青春期发育阶段的广义线性回归分析中，超重或肥胖儿童和青少年的 OSA 或 AHI 与 HRQOL 之间无关联。在包括无 OSA 的儿童和青少年和正常体重对照组的分析中，调整年龄、性别和 AHI 的广义线性回归显示 BMI SDS 与 HRQOL 之间存在关联（p<0.001）。
结论
我们发现超重或肥胖儿童和青少年的 AHI 或 OSA 与 HRQOL 之间无关联。然而，我们发现无 OSA 的儿童和青少年的 BMI SDS 与 HRQOL 之间存在关联。
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